Decidual vasculopathy in preeclampsia: Lesion characteristics relate to disease severity and perinatal outcome

Abstract Objective In a proportion of patients with preeclampsia, unremodeled spiral arteries develop additional pathological changes, termed decidual vasculopathy (DV), or acute atherosis. DV has been correlated to adverse clinical outcome and increased placental pathology. However, it was unclear...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2013-09, Vol.34 (9), p.805-809
Main Authors: Stevens, D.U, Al-Nasiry, S, Bulten, J, Spaanderman, M.E.A
Format: Article
Language:English
Subjects:
Acute atherosis
Adult
Basement Membrane - blood supply
Basement Membrane - immunology
Basement Membrane - pathology
Biological and medical sciences
Birth Weight
Clinical outcome
Decidua - blood supply
Decidua - immunology
Decidua - pathology
Embryology: invertebrates and vertebrates. Teratology
Female
Foam Cells - immunology
Foam Cells - pathology
Fundamental and applied biological sciences. Psychology
Humans
Infant, Newborn
Internal Medicine
Macrophage Activation
Male
Netherlands - epidemiology
Obstetrics and Gynecology
Perinatal Mortality
Placenta - blood supply
Placenta - immunology
Placenta - pathology
Pre-Eclampsia - immunology
Pre-Eclampsia - mortality
Pre-Eclampsia - pathology
Pre-Eclampsia - physiopathology
Preeclampsia
Pregnancy
Pregnancy Outcome
Premature Birth - etiology
Proteinuria - etiology
Retrospective Studies
Severity of Illness Index
Thrombosis - etiology
Vascular Diseases - etiology
Vasculopathy
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Summary:Abstract Objective In a proportion of patients with preeclampsia, unremodeled spiral arteries develop additional pathological changes, termed decidual vasculopathy (DV), or acute atherosis. DV has been correlated to adverse clinical outcome and increased placental pathology. However, it was unclear whether these effects pertained to individual features of DV. Methods We performed a reanalysis of placental samples from preeclamptic pregnancies ( n  = 76), recording the number of vessels with DV, their location in the decidua and their morphological features. Results were correlated with clinical and placental parameters, using Spearman's rho test. P -value 
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2013.05.008