Endogenous plasma coenzyme Q10 concentration does not correlate with plasma total antioxidant capacity level in healthy untrained horses

Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial electron transport pathway, and is also the only known endogenously synthesized lipid-soluble antioxidant. The aim of the present study was to determine, for the first time, endogenous plasma CoQ10 concentration and its correlation w...

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Bibliographic Details
Published in:Research in veterinary science 2013-10, Vol.95 (2), p.675-677
Main Authors: Bohar Topolovec, Mojca, Kruljc, Peter, Prošek, Mirko, Jazbec Križman, Petra, Šmidovnik, Andrej, Nemec Svete, Alenka
Format: Article
Language:English
Subjects:
Animals
antioxidant activity
Antioxidants
Antioxidants - metabolism
blood serum
Cholesterol
Coenzyme Q10
electron transfer
Female
Gene Expression Regulation, Enzymologic
Hematology
Horse
Horses
Horses - blood
Horses - physiology
humans
Lipids
Male
Physical Conditioning, Animal - physiology
Plasma
Population
Software
Standard deviation
Total antioxidant capacity
Total cholesterol
Ubiquinone - analogs & derivatives
Ubiquinone - blood
Ubiquinone - genetics
Ubiquinone - metabolism
Veterinary medicine
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Summary:Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial electron transport pathway, and is also the only known endogenously synthesized lipid-soluble antioxidant. The aim of the present study was to determine, for the first time, endogenous plasma CoQ10 concentration and its correlation with plasma total antioxidant capacity (TAC) and serum total cholesterol (TC) in a population of healthy untrained horses. Thirty-one horses were included in the study. Plasma CoQ10 concentration ranged from 0.380 to 2.090mg/L, which is in general agreement with plasma CoQ10 concentration in humans. The study demonstrated no significant correlation between plasma CoQ10 and TAC, which indicates that CoQ10 does not contribute to the TAC of equine plasma significantly. In contrast to humans, no significant correlation was found between CoQ10 and TC in investigated horses. The results warrant further studies on CoQ10 supplementation in healthy untrained horses and subsequent determination of correlations between CoQ10 and TAC.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2013.03.020