Breakdown of the Debye polarization ansatz at protein-water interfaces

The topographical and physico-chemical complexity of protein-water interfaces scales down to the sub-nanoscale range. At this level of confinement, we demonstrate that the dielectric structure of interfacial water entails a breakdown of the Debye ansatz that postulates the alignment of polarization...

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Bibliographic Details
Published in:The Journal of chemical physics 2013-06, Vol.138 (22), p.225103-225103
Main Author: Fernández Stigliano, Ariel
Format: Article
Language:English
Subjects:
Animals
Humans
Models, Molecular
Proteins - chemistry
src Homology Domains
Static Electricity
Water - chemistry
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Summary:The topographical and physico-chemical complexity of protein-water interfaces scales down to the sub-nanoscale range. At this level of confinement, we demonstrate that the dielectric structure of interfacial water entails a breakdown of the Debye ansatz that postulates the alignment of polarization with the protein electrostatic field. The tendencies to promote anomalous polarization are determined for each residue type and a particular kind of structural defect is shown to provide the predominant causal context.
ISSN:0021-9606
1089-7690
DOI:10.1063/1.4810867