Effect of Coadministration of Uracil on the Toxicity of Tegafur

The cardiotoxic and neurotoxic effects of tegafur, an anticancer agent, were compared with those of uracil plus tegafur (4:1 mol/mol) in mice, rats, rabbits, cats and dogs. Uracil plus tegafur was shown to be less toxic than the drug alone in all the species, and uracil was found to decrease the tox...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 1984-02, Vol.73 (2), p.212-214
Main Authors: Yamamoto, Jyunji, Haruno, Akihiro, Yoshimura, Yuji, Unemi, Norio, Kunimune, Yoshio, Yamashita, Kazumasa, Morita, Ken'Ichi
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
beta-Alanine - analogs & derivatives
beta-Alanine - toxicity
Biological and medical sciences
Cats
Chemotherapeutic agents-coadministration of tegafur and uracil
Chemotherapeutic agents—coadministration of tegafur and uracil, effect on toxicity, species comparison
Dogs
effect on toxicity
Female
Fluorouracil - analogs & derivatives
General aspects
Heart Diseases - chemically induced
Lethal Dose 50
Male
Medical sciences
Mice
Nervous System Diseases - chemically induced
Pharmacology. Drug treatments
Rabbits
Rats
Rats, Inbred Strains
species comparison
Species Specificity
Tegafur - antagonists & inhibitors
Tegafur - toxicity
Tegafur-coadministration with uracil
Tegafur—coadministration with uracil, effect on toxicity, species comparison
Uracil - pharmacology
Uracil-coadministration with tegafur
Uracil—coadministration with tegafur, effect on toxicity, species comparison
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The cardiotoxic and neurotoxic effects of tegafur, an anticancer agent, were compared with those of uracil plus tegafur (4:1 mol/mol) in mice, rats, rabbits, cats and dogs. Uracil plus tegafur was shown to be less toxic than the drug alone in all the species, and uracil was found to decrease the toxicity of tegafur. α-Fluoro-β-alanine, a catabolic metabolite of the drug, had toxic effects similar to tegafur. The results suggest that administration of uracil with tegafur prevents the side effects of the drug on the heart and CNS by inhibiting the degradation of 5-fluorouracil.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600730217