In vitro effect of monocrotophos on human lymphocytes

The chromosomal damaging effects of monocrotophos, an organophosphate pesticide, were studied in human lymphocyte cultures. Aberrations observed include chromatid breaks, gaps, deletions, fragments, exchanges, dicentrics, and endoreduplications. A dose-dependent increase was observed in the frequenc...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1988-11, Vol.41 (5), p.737-741
Main Authors: Rupa, D.S, Lakshman Rao, P.V, Reddy, P.P, Reddi, O.S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells, Cultured
Chemical mutagenesis
CHROMOSOME
Chromosome Aberrations
CHROMOSOMES
CROMOSOMAS
GOSSYPIUM
Humans
INDE
INDIA
INSECTICIDAS
INSECTICIDE
INSECTICIDES
Insecticides - toxicity
LINFOCITOS
LYMPHOCYTE
LYMPHOCYTES
Lymphocytes - drug effects
Lymphocytes - ultrastructure
Male
Medical sciences
Monocrotophos - toxicity
OCCUPATIONAL HAZARDS
PESTICIDE
PESTICIDES
PLAGUICIDAS
RESIDU
RESIDUES
RESIDUOS
RIESGOS OCUPACIONALES
RISQUE PROFESSIONNEL
Sister Chromatid Exchange
Toxicology
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Summary:The chromosomal damaging effects of monocrotophos, an organophosphate pesticide, were studied in human lymphocyte cultures. Aberrations observed include chromatid breaks, gaps, deletions, fragments, exchanges, dicentrics, and endoreduplications. A dose-dependent increase was observed in the frequency of gaps and breaks with a corresponding increase in duration of exposure. A significant increase in sister chromatid exchanges at all concentrations and at different time intervals reveals that chromosomes are sensitive to damage by the compound. Sister chromatid exchanges are a more sensitive indicator than chromosomal aberrations.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF02021026