Mortality in middle-aged men with obstructive sleep apnea in Finland

Introduction Obstructive sleep apnea (OSA) has been associated with an elevated rate of cardiovascular mortality. However, this issue has not been investigated in patients with elevated proneness to cardiovascular diseases. Our hypothesis was that OSA would have an especially adverse effect on the r...

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Bibliographic Details
Published in:Sleep & breathing 2013-09, Vol.17 (3), p.1047-1053
Main Authors: Muraja-Murro, A., Eskola, K., Kolari, T., Tiihonen, P., Hukkanen, T., Tuomilehto, H., Peltonen, M., Mervaala, E., Töyräs, J.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Body Mass Index
Cardiovascular disease
Cause of Death
Coronary Disease - classification
Coronary Disease - diagnosis
Coronary Disease - mortality
Dentistry
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Finland
Fundamental and applied biological sciences. Psychology
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Humans
Internal Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Mens health
Middle Aged
Mortality
Nervous system (semeiology, syndromes)
Neurology
Original Article
Otorhinolaryngology
Pediatrics
Pneumology/Respiratory System
Polysomnography
Proportional Hazards Models
Retrospective Studies
Risk
Sleep apnea
Sleep Apnea, Obstructive - classification
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - mortality
Sleep. Vigilance
Smoking - adverse effects
Smoking - mortality
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the upper aerodigestive tract
Survival Rate
Vertebrates: nervous system and sense organs
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Summary:Introduction Obstructive sleep apnea (OSA) has been associated with an elevated rate of cardiovascular mortality. However, this issue has not been investigated in patients with elevated proneness to cardiovascular diseases. Our hypothesis was that OSA would have an especially adverse effect on the risk of cardiovascular mortality in Finnish individuals exhibiting elevated proneness for coronary heart diseases. Methods Ambulatory polygraphic recordings from 405 men having suspected OSA were retrospectively analyzed. The patients were categorized regarding sleep disordered breathing into a normal group (apnea hypopnea index (AHI) 
ISSN:1520-9512
1522-1709
DOI:10.1007/s11325-012-0798-8