The success rate of pregnancy in IUI cycles following endometrial sampling. A randomized controlled study: Endometrial sampling and pregnancy rates

Objective The aim of this work was to compare the pregnancy rates during IUI cycles with or without endometrial sampling. Study design A prospective, randomized study. Patients and methods 150 patients were recruited. They were classified into three groups. Each comprised 50 patients. Group 1 was co...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2013-09, Vol.288 (3), p.673-678
Main Author: Abdelhamid, Amr M. Salaheldin
Format: Article
Language:English
Subjects:
Adult
Biopsy
Endocrinology
Endometrium - immunology
Endometrium - injuries
Endometrium - pathology
Female
Follicular Phase - immunology
Gynecology
Human Genetics
Humans
Insemination, Artificial
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pregnancy
Pregnancy Rate
Reproductive Medicine
Young Adult
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Summary:Objective The aim of this work was to compare the pregnancy rates during IUI cycles with or without endometrial sampling. Study design A prospective, randomized study. Patients and methods 150 patients were recruited. They were classified into three groups. Each comprised 50 patients. Group 1 was considered the control group and underwent IUI with no endometrial sampling. Group 2 underwent Tao Brush endometrial sampling on day 8–9 of the uterine cycle that preceded the stimulation cycle, and finally, Group 3 underwent Tao Brush endometrial sampling on day 8–9 of the same IUI cycle Outcome of the study A positive pregnancy test. Results Pregnancy percentages were 18, 38, and 36 % for group 1, group 2, and group 3, respectively. The paired t test was used to compare each two individual group means. The results show a highly significant value for the paired t test of the control group and group 2 of the patients ( p  = 0.001), as well as a highly significant results ( p  = 0.002) for the group 3 and the control group. No significant value was present between the group 2 and 3 of patients ( p  = 0.322). Conclusion Endometrial sampling significantly increases pregnancy rates in IUI procedures when it is done in the proliferative phase of the IUI cycle, or the cycle prior to IUI, than pregnancy rates with IUI alone.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-013-2785-0