Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites

In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microsco...

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Bibliographic Details
Published in:Parasitology research (1987) 2013-09, Vol.112 (9), p.3251-3257
Main Authors: Pérez-Rangel, Armando, Hernández, José Manuel, Castillo-Romero, Araceli, Yépez-Mulia, Lilián, Castillo, Rafael, Hernández-Luis, Francisco, Nogueda-Torres, Benjamín, Luna-Arias, Juan Pedro, Radilla, Gerardo, León-Avila, Gloria
Format: Article
Language:English
Subjects:
Albendazole
Albendazole - analogs & derivatives
Albendazole - pharmacology
Animals
Anthelmintics - pharmacology
Antibodies, Protozoan - immunology
Biomedical and Life Sciences
Biomedicine
cytoskeleton
Dosage and administration
Drug interactions
encystment
Gene Expression Regulation
Giardia
Giardia - drug effects
Giardia - growth & development
Giardia - immunology
Giardia - ultrastructure
Giardia lamblia
Health aspects
Host-parasite relationships
Immunology
Medical Microbiology
Mice
Mice, Inbred BALB C
Microbiology
Microscopy, Confocal
Microscopy, Electron, Scanning
Original Paper
Physiological aspects
Protozoan Proteins - immunology
Protozoan Proteins - metabolism
Rats
Rats, Wistar
Recombinant Proteins
scanning electron microscopy
trophozoites
Trophozoites - drug effects
Trophozoites - growth & development
Trophozoites - immunology
Trophozoites - ultrastructure
Tubulin - metabolism
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Summary:In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-013-3521-1