Cytoskeletal accumulation of a specific iso-actin during chemotaxis of Dictyostelium

We have previously reported that stimulation of Dictyostelium amoebae with the chemoattractants folate or cAMP elicits a rapid (3–5 s) accumulation of actin in the Triton-insoluble cytoskeleton, a response which may be involved in amoeboid movement (McRobbie and Newell, 1983, 1984). We have now meas...

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Bibliographic Details
Published in:FEBS letters 1985-02, Vol.181 (1), p.100-102
Main Authors: McRobbie, Stuart J., Newell, Peter C.
Format: Article
Language:English
Subjects:
5'-cyclic adenosine monophosphate
Actin isoform
Biochemistry. Physiology. Immunology. Molecular biology
Biological and medical sciences
cAMP
Chemotaxis
Cytoskeleton
Dictyostelium
Dictyostelium discoideum
Fundamental and applied biological sciences. Psychology
Protozoa
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Summary:We have previously reported that stimulation of Dictyostelium amoebae with the chemoattractants folate or cAMP elicits a rapid (3–5 s) accumulation of actin in the Triton-insoluble cytoskeleton, a response which may be involved in amoeboid movement (McRobbie and Newell, 1983, 1984). We have now measured the changes in the three major isoactin species A 1 A 2, and A 3 present in the amoebal cytoskeletons and find that it is the most acidic isoactin A 1 that preferentially accumulates in the cytoskeleton in response to these chemotactic pulses. The differing roles of the isoactins are discussed
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(85)81121-2