Fat Deposition in Dilated Cardiomyopathy Assessed by CMR

• Published in: JACC. Cardiovascular imaging 2013-08, Vol.6 (8), p.889-898
• Main Authors: Lu, Minjie, MD, PhD, Zhao, Shihua, MD, Jiang, Shiliang, MD, Yin, Gang, BS, Wang, Cheng, MD, Zhang, Yan, MD, Liu, Qiong, PhD, Cheng, Huaibing, PhD, Ma, Ning, PhD, Zhao, Tao, PhD, Chen, Xiuyu, PhD, Huang, Jinghan, MD, Zou, Yubao, PhD, Song, Lei, MD, He, Zuoxiang, PhD, An, Jing, MD, Renate, Jerecic, PhD, Xue, Hui, PhD, Shah, Saurabh, PhD
• Format: Article
• Language: English
• Subjects: Adipose Tissue - pathology; Adult; Aged; Cardiomyopathy, Dilated - pathology; Cardiomyopathy, Dilated - physiopathology; Cardiovascular; Contrast Media; Female; Fibrosis; Gadolinium DTPA; Humans; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardium - pathology; Predictive Value of Tests; Prospective Studies; Stroke Volume; Ventricular Function, Left
• ISSN: 1936-878X; 1876-7591
• DOI: 10.1016/j.jcmg.2013.04.010

Objectives The aim of this study was to prospectively investigate the prevalence of fat deposition in idiopathic dilated cardiomyopathy (DCM) by fat-water separation imaging. An auxiliary aim was to determine the relationship between left ventricular (LV) fat deposition and characteristic myocardial fibrosis, as well as cardiac functional parameters. Background Idiopathic DCM remains the most common cause of heart failure in young people referred for cardiac transplantation; little is known about the clinical value of fat deposition in DCM. Methods A total of 124 patients with DCM were studied after written informed consent was obtained. The magnetic resonance imaging scan protocols included a series of short-axis LV cine imaging for functional analysis, fat-water separation imaging, and late gadolinium enhancement (LGE) imaging. Fat deposition and fibrosis location were compared to the scar regions on LGE images using a 17-segment model. Statistical comparisons of LV global functional parameters, fibrosis volumes, and fat deposition were carried out using the Pearson correlation, Student t test, and multiple regressions. Results The patients had a 41.9% (52 of 124) prevalence of positive LGE, and 12.9% (16 of 124) fat deposition prevalence was found in this DCM cohort. The patients with fat deposition had larger LV end-diastolic volume (LVEDV) index (140.8 ± 20.2 ml/m2 vs. 123.4 ± 15.8 ml/m2 ; p < 0.01), larger LV end-systolic volume (LVESV) index (111.3 ± 19.2 ml/m2 vs. 87.0 ± 20.3 ml/m2 ; p < 0.01), and decreased LV ejection fraction (LVEF) (21.1 ± 7.1% vs. 30.0 ± 10.7%; p < 0.01). Higher volumes of LGE were found in the group with myocardial fat deposition (18.39 ± 9.0 ml vs. 13.40 ± 6.54 ml; p = 0.001), as well as a higher percentage of LGE/LV mass (19.11 ± 7.78% vs. 13.60 ± 4.58%; p = 0.000). The volume of fat deposition was correlated with scar volume, LVEF, LVEDV index, and LVESV index. Conclusions Fat deposition is a common phenomenon in DCM, and it is associated with DCM characteristics such as fibrosis volume and LV function.