Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats

• Published in: Pharmacological reports 2013, Vol.65 (3), p.658-665
• Main Authors: Kondamudi, Phani Krishna, Kovelamudi, Hemalatha, Mathew, Geetha, Nayak, Pawan G., Rao, C. Mallikarjuna, Shenoy, Rekha R.
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants - pharmacology; Benzodioxoles - pharmacology; Body Weight - drug effects; Colon; dinitrochlorobenzene; Dinitrochlorobenzene - adverse effects; Drug Safety and Pharmacovigilance; Granulocyte Colony-Stimulating Factor - metabolism; Inflammatory Bowel Diseases - blood; Inflammatory Bowel Diseases - chemically induced; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - metabolism; Interleukin-3 - metabolism; interleukin-6; Interleukin-6 - metabolism; Male; myeloperoxidase; Nitrites - blood; Nitrites - metabolism; Pharmacotherapy; Pharmacy; Phenols - pharmacology; Rats; Rats, Wistar; Recombinant Fusion Proteins - metabolism; sesamol; TBARS; Thiobarbituric Acid Reactive Substances - metabolism; TNF-α; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 1734-1140; 2299-5684
• DOI: 10.1016/S1734-1140(13)71043-0

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal tract of immune, genetic and environmental origin. In the present study, we examined the effect of sesamol (SES), the main anti-oxidative constituent of Sesamum indicum (sesame seed) Linn. in the dinitrochlorobenzene (DNCB)-induced model for IBD in rats. The groups were divided into normal control, DNCB control, SES and sulfasalazine (SS). On day 24, the rats were killed, colon removed and the macroscopic, biochemical and histopathological evaluations were performed. The levels of MPO, TBARS and nitrite increased significantly (p