In Vitro Interaction of Neuroleptics and Tricylic Antidepressants with Coffee, Tea, and Gallotannic Acid

The in vitro interaction of selected drugs with coffee, tea, gallic acid, and gallotannic acid was examined by mixing solutions of drug with each of these four preparations. Results of these experiments indicate that significant precipitation occurs for a variety of agents, including several phenoth...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1984-08, Vol.73 (8), p.1056-1058
Main Authors: Lasswell, William L., Weber, Stanley S., Wilkins, John M.
Format: Article
Language:English
Subjects:
and gallic acid
Antidepressive Agents, Tricyclic
Antipsychotic Agents
Biological and medical sciences
Chemical Phenomena
Chemistry
Coffee
Drug Interactions
Gallic Acid
gallotannic acid
General aspects
Hydrogen-Ion Concentration
Hydrolyzable Tannins
Medical sciences
Neuroleptics-in vitro interaction with coffee
Neuroleptics—in vitro interaction with coffee, tea, gallotannic acid, and gallic acid
Neuropharmacology
Pharmacology. Drug treatments
Tannins
Tea
Tricyclic antidepressants-in vitro interaction with coffee
Tricyclic antidepressants—in vitro interaction with coffee, tea, gallotannic acid, and gallic acid
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Summary:The in vitro interaction of selected drugs with coffee, tea, gallic acid, and gallotannic acid was examined by mixing solutions of drug with each of these four preparations. Results of these experiments indicate that significant precipitation occurs for a variety of agents, including several phenothiazines, amitriptyline, haloperidol, imipramine, and loxapine. The strong complex which is formed between these drugs and tannins is probably the basis of the interaction of these drugs with coffee and tea. Although precipitates did occur with a number of neuroleptics, two members of this drug class, thiothixene and molindone, failed to interact with the solutions used.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600730809