Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Background & Aims Obesity is closely related to non-alcoholic fatty liver disease (NAFLD), which has become an important public health problem because of its high prevalence and association with metabolic syndromes. Irisin was recently identified as a novel peptide to improve obesity and glucose...

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Bibliographic Details
Published in:Journal of hepatology 2013-09, Vol.59 (3), p.557-562
Main Authors: Zhang, Hui-Jie, Zhang, Xian-Feng, Ma, Zhi-Min, Pan, Ling-Ling, Chen, Zheng, Han, Hai-Wei, Han, Cheng-Kun, Zhuang, Xiong-Jie, Lu, Yan, Li, Xue-Jun, Yang, Shu-Yu, Li, Xiao-Ying
Format: Article
Language:English
Subjects:
Adult
Aged
Alanine Transaminase - blood
Asian Continental Ancestry Group
Aspartate Aminotransferases - blood
China
Cross-Sectional Studies
Fatty Liver - blood
Fatty Liver - complications
Fatty Liver - metabolism
Female
Fibronectins - blood
Gastroenterology and Hepatology
Humans
Intrahepatic triglyceride content
Irisin
Liver - enzymology
Liver - metabolism
Magnetic Resonance Spectroscopy
Male
Middle Aged
Non-alcoholic Fatty Liver Disease
Obesity
Obesity - blood
Obesity - complications
Obesity - metabolism
Triglycerides - metabolism
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Summary:Background & Aims Obesity is closely related to non-alcoholic fatty liver disease (NAFLD), which has become an important public health problem because of its high prevalence and association with metabolic syndromes. Irisin was recently identified as a novel peptide to improve obesity and glucose homeostasis, and considered to be therapeutic for human metabolic diseases. The aim of this study was to examine the association of serum irisin concentration and liver triglyceride contents in obese Chinese adults. Methods Serum irisin levels were measured and liver fat contents determined by1 H MRS in 296 obese adults. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose, and lipid profiles were detected. The liver triglyceride contents of subjects were measured by1 H MRS. The protein levels of irisin were determined by quantitative ELISA. Results We found that serum irisin levels were reduced in obese adults with NAFLD. By dividing the distribution of intrahepatic triglyceride (IHTG) contents into quartiles, serum irisin levels were reduced gradually with the increase of IHTG contents ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2013.04.030