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Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients?
Objectives To evaluate the prognostic role of the lymph node ratio (LNR; ratio of total positive nodes to total dissected nodes) in oral squamous cell carcinoma (OSCC) as compared to pN staging with an aim to provide an optimal cut‐off value. Methods 1,408 OSCC previously untreated patients who unde...
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| Published in: | Journal of surgical oncology 2013-09, Vol.108 (4), p.256-263 |
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| cites | cdi_FETCH-LOGICAL-c4577-e126d73933824f78f8abacd4b3ae70ccba667e098922a5d05c52219977b083db3 |
| container_end_page | 263 |
| container_issue | 4 |
| container_start_page | 256 |
| container_title | Journal of surgical oncology |
| container_volume | 108 |
| creator | Sayed, Suhail I. Sharma, Shilpi Rane, Pawan Vaishampayan, Sagar Talole, Sanjay Chaturvedi, Pankaj Chaukar, Devendra Deshmukh, Anuja Agarwal, Jai Prakash D'cruz, Anil K. |
| description | Objectives
To evaluate the prognostic role of the lymph node ratio (LNR; ratio of total positive nodes to total dissected nodes) in oral squamous cell carcinoma (OSCC) as compared to pN staging with an aim to provide an optimal cut‐off value.
Methods
1,408 OSCC previously untreated patients who underwent treatment (surgery + neck dissection + adjuvant treatment). LNR sensitivity with respect to survival was calculated using receiver operating characteristic (ROC) curves and Cox regression method. LNR and TNM staging variables were subjected to multivariate analysis.
Results
LNR (0.088) showed significant association with survival outcomes. For patients with LNR ≤0.088, the OS, DFS, local control, regional control and distant metastasis rates were 64%, 70%, and 89%; for LNR >0.088 it was 22%, 19%, and 52%, respectively (P |
| doi_str_mv | 10.1002/jso.23387 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1426510886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1426510886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4577-e126d73933824f78f8abacd4b3ae70ccba667e098922a5d05c52219977b083db3</originalsourceid><addsrcrecordid>eNp1kElPHDEQhS2UKExIDvkDyFIucGgob-32CaERYdGwiASQcrHcbo_w0Bt29yTz7zEZ4ICU05OqvvdU9RD6RmCPAND9Rez2KGOF3EATAirPFKjiA5qkHc24VLCJPse4AAClcv4JbVJWKCYIn6DbqWlx4wYTBzN4i-tV09_jtqscDmnQ4Z3ZxfUu7oOrvB1wHMPSL02NfYu7kNSapR9WSVrrAu6TxbVDPPiCPs5NHd3XF91CNz-Ofk1Pstnl8en0cJZZLqTMHKF5JZlKt1M-l8W8MKWxFS-ZcRKsLU2eS5eeUZQaUYGwglKilJQlFKwq2RbaWef2oXscXRx046N1dW1a141RE05zQaAo8oR-f4cuujG06bpEcSZAcIBE7a4pG7oYg5vrPvjGhJUmoJ_L1qls_a_sxG6_JI5l46o38rXdBOyvgT--dqv_J-mzn5evkdna4ePg_r45THjQuWRS6LuLY31yxa7uzn9f61v2BBxclpY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443505400</pqid></control><display><type>article</type><title>Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients?</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Sayed, Suhail I. ; Sharma, Shilpi ; Rane, Pawan ; Vaishampayan, Sagar ; Talole, Sanjay ; Chaturvedi, Pankaj ; Chaukar, Devendra ; Deshmukh, Anuja ; Agarwal, Jai Prakash ; D'cruz, Anil K.</creator><creatorcontrib>Sayed, Suhail I. ; Sharma, Shilpi ; Rane, Pawan ; Vaishampayan, Sagar ; Talole, Sanjay ; Chaturvedi, Pankaj ; Chaukar, Devendra ; Deshmukh, Anuja ; Agarwal, Jai Prakash ; D'cruz, Anil K.</creatorcontrib><description>Objectives
To evaluate the prognostic role of the lymph node ratio (LNR; ratio of total positive nodes to total dissected nodes) in oral squamous cell carcinoma (OSCC) as compared to pN staging with an aim to provide an optimal cut‐off value.
Methods
1,408 OSCC previously untreated patients who underwent treatment (surgery + neck dissection + adjuvant treatment). LNR sensitivity with respect to survival was calculated using receiver operating characteristic (ROC) curves and Cox regression method. LNR and TNM staging variables were subjected to multivariate analysis.
Results
LNR (0.088) showed significant association with survival outcomes. For patients with LNR ≤0.088, the OS, DFS, local control, regional control and distant metastasis rates were 64%, 70%, and 89%; for LNR >0.088 it was 22%, 19%, and 52%, respectively (P < 0.001). On multivariate analysis LNR of 0.088 was seen to be an independent prognostic factor for 5‐year regional control (p, hazard ratio [95% confidence interval]; 0.044, 2.016 (1.019–3.990), DFS, 0.032, 1.858 (1.054–3.276), and OS, 0.040, 1.195 (1.033–1.144). On multivariate analysis LNR categorization showed a statistically significant [0.032, 1.858, (1.054–3.276)] advantage over pN staging [0.527, 1.208 (1.054–3.276)] in predicting survival.
Conclusions
LNR is a better prognostic marker than the current N staging of TNM classification. J. Surg. Oncol. 2013 108:256–263. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23387</identifier><identifier>PMID: 23893514</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Confidence intervals ; Female ; Follow-Up Studies ; Humans ; Lymph Node Excision ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Medical research ; metastatic lymph node ratio ; Middle Aged ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Multivariate analysis ; neck metastasis ; Neoplasm Recurrence, Local ; Neoplasm Staging ; oral cavity cancer ; Proportional Hazards Models ; Retrospective Studies</subject><ispartof>Journal of surgical oncology, 2013-09, Vol.108 (4), p.256-263</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4577-e126d73933824f78f8abacd4b3ae70ccba667e098922a5d05c52219977b083db3</citedby><cites>FETCH-LOGICAL-c4577-e126d73933824f78f8abacd4b3ae70ccba667e098922a5d05c52219977b083db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23893514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sayed, Suhail I.</creatorcontrib><creatorcontrib>Sharma, Shilpi</creatorcontrib><creatorcontrib>Rane, Pawan</creatorcontrib><creatorcontrib>Vaishampayan, Sagar</creatorcontrib><creatorcontrib>Talole, Sanjay</creatorcontrib><creatorcontrib>Chaturvedi, Pankaj</creatorcontrib><creatorcontrib>Chaukar, Devendra</creatorcontrib><creatorcontrib>Deshmukh, Anuja</creatorcontrib><creatorcontrib>Agarwal, Jai Prakash</creatorcontrib><creatorcontrib>D'cruz, Anil K.</creatorcontrib><title>Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients?</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Objectives
To evaluate the prognostic role of the lymph node ratio (LNR; ratio of total positive nodes to total dissected nodes) in oral squamous cell carcinoma (OSCC) as compared to pN staging with an aim to provide an optimal cut‐off value.
Methods
1,408 OSCC previously untreated patients who underwent treatment (surgery + neck dissection + adjuvant treatment). LNR sensitivity with respect to survival was calculated using receiver operating characteristic (ROC) curves and Cox regression method. LNR and TNM staging variables were subjected to multivariate analysis.
Results
LNR (0.088) showed significant association with survival outcomes. For patients with LNR ≤0.088, the OS, DFS, local control, regional control and distant metastasis rates were 64%, 70%, and 89%; for LNR >0.088 it was 22%, 19%, and 52%, respectively (P < 0.001). On multivariate analysis LNR of 0.088 was seen to be an independent prognostic factor for 5‐year regional control (p, hazard ratio [95% confidence interval]; 0.044, 2.016 (1.019–3.990), DFS, 0.032, 1.858 (1.054–3.276), and OS, 0.040, 1.195 (1.033–1.144). On multivariate analysis LNR categorization showed a statistically significant [0.032, 1.858, (1.054–3.276)] advantage over pN staging [0.527, 1.208 (1.054–3.276)] in predicting survival.
Conclusions
LNR is a better prognostic marker than the current N staging of TNM classification. J. Surg. Oncol. 2013 108:256–263. © 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical research</subject><subject>metastatic lymph node ratio</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Multivariate analysis</subject><subject>neck metastasis</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>oral cavity cancer</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kElPHDEQhS2UKExIDvkDyFIucGgob-32CaERYdGwiASQcrHcbo_w0Bt29yTz7zEZ4ICU05OqvvdU9RD6RmCPAND9Rez2KGOF3EATAirPFKjiA5qkHc24VLCJPse4AAClcv4JbVJWKCYIn6DbqWlx4wYTBzN4i-tV09_jtqscDmnQ4Z3ZxfUu7oOrvB1wHMPSL02NfYu7kNSapR9WSVrrAu6TxbVDPPiCPs5NHd3XF91CNz-Ofk1Pstnl8en0cJZZLqTMHKF5JZlKt1M-l8W8MKWxFS-ZcRKsLU2eS5eeUZQaUYGwglKilJQlFKwq2RbaWef2oXscXRx046N1dW1a141RE05zQaAo8oR-f4cuujG06bpEcSZAcIBE7a4pG7oYg5vrPvjGhJUmoJ_L1qls_a_sxG6_JI5l46o38rXdBOyvgT--dqv_J-mzn5evkdna4ePg_r45THjQuWRS6LuLY31yxa7uzn9f61v2BBxclpY</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Sayed, Suhail I.</creator><creator>Sharma, Shilpi</creator><creator>Rane, Pawan</creator><creator>Vaishampayan, Sagar</creator><creator>Talole, Sanjay</creator><creator>Chaturvedi, Pankaj</creator><creator>Chaukar, Devendra</creator><creator>Deshmukh, Anuja</creator><creator>Agarwal, Jai Prakash</creator><creator>D'cruz, Anil K.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients?</title><author>Sayed, Suhail I. ; Sharma, Shilpi ; Rane, Pawan ; Vaishampayan, Sagar ; Talole, Sanjay ; Chaturvedi, Pankaj ; Chaukar, Devendra ; Deshmukh, Anuja ; Agarwal, Jai Prakash ; D'cruz, Anil K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4577-e126d73933824f78f8abacd4b3ae70ccba667e098922a5d05c52219977b083db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical research</topic><topic>metastatic lymph node ratio</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Multivariate analysis</topic><topic>neck metastasis</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>oral cavity cancer</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sayed, Suhail I.</creatorcontrib><creatorcontrib>Sharma, Shilpi</creatorcontrib><creatorcontrib>Rane, Pawan</creatorcontrib><creatorcontrib>Vaishampayan, Sagar</creatorcontrib><creatorcontrib>Talole, Sanjay</creatorcontrib><creatorcontrib>Chaturvedi, Pankaj</creatorcontrib><creatorcontrib>Chaukar, Devendra</creatorcontrib><creatorcontrib>Deshmukh, Anuja</creatorcontrib><creatorcontrib>Agarwal, Jai Prakash</creatorcontrib><creatorcontrib>D'cruz, Anil K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sayed, Suhail I.</au><au>Sharma, Shilpi</au><au>Rane, Pawan</au><au>Vaishampayan, Sagar</au><au>Talole, Sanjay</au><au>Chaturvedi, Pankaj</au><au>Chaukar, Devendra</au><au>Deshmukh, Anuja</au><au>Agarwal, Jai Prakash</au><au>D'cruz, Anil K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients?</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>108</volume><issue>4</issue><spage>256</spage><epage>263</epage><pages>256-263</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Objectives
To evaluate the prognostic role of the lymph node ratio (LNR; ratio of total positive nodes to total dissected nodes) in oral squamous cell carcinoma (OSCC) as compared to pN staging with an aim to provide an optimal cut‐off value.
Methods
1,408 OSCC previously untreated patients who underwent treatment (surgery + neck dissection + adjuvant treatment). LNR sensitivity with respect to survival was calculated using receiver operating characteristic (ROC) curves and Cox regression method. LNR and TNM staging variables were subjected to multivariate analysis.
Results
LNR (0.088) showed significant association with survival outcomes. For patients with LNR ≤0.088, the OS, DFS, local control, regional control and distant metastasis rates were 64%, 70%, and 89%; for LNR >0.088 it was 22%, 19%, and 52%, respectively (P < 0.001). On multivariate analysis LNR of 0.088 was seen to be an independent prognostic factor for 5‐year regional control (p, hazard ratio [95% confidence interval]; 0.044, 2.016 (1.019–3.990), DFS, 0.032, 1.858 (1.054–3.276), and OS, 0.040, 1.195 (1.033–1.144). On multivariate analysis LNR categorization showed a statistically significant [0.032, 1.858, (1.054–3.276)] advantage over pN staging [0.527, 1.208 (1.054–3.276)] in predicting survival.
Conclusions
LNR is a better prognostic marker than the current N staging of TNM classification. J. Surg. Oncol. 2013 108:256–263. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23893514</pmid><doi>10.1002/jso.23387</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of surgical oncology, 2013-09, Vol.108 (4), p.256-263 |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Confidence intervals Female Follow-Up Studies Humans Lymph Node Excision Lymph Nodes - pathology Lymphatic Metastasis Male Medical research metastatic lymph node ratio Middle Aged Mouth Neoplasms - mortality Mouth Neoplasms - pathology Multivariate analysis neck metastasis Neoplasm Recurrence, Local Neoplasm Staging oral cavity cancer Proportional Hazards Models Retrospective Studies |
| title | Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients? |
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