Hybrid PET/MR imaging of tumors using an oleanolic acid-conjugated nanoparticle

Abstract Research into multifunctional nanoparticles is focused on creating an agent for use in an all-in-one multimodal imaging system that includes diagnostic imaging, drug delivery, and therapeutic monitoring. We designed a new dual-modality tumor-targeting agent with a new tumor-targeting molecu...

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Bibliographic Details
Published in:Biomaterials 2013-11, Vol.34 (33), p.8114-8121
Main Authors: Kim, Sung-min, Chae, Min Kyung, Yim, Min Su, Jeong, Il Ha, Cho, Janggeun, Lee, Chulhyun, Ryu, Eun Kyoung
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Cell Proliferation - drug effects
Colon cancer
Colonic Neoplasms - diagnosis
Dentistry
Diagnosis
Ferric Compounds - chemistry
HT29 Cells
Humans
Iron oxide nanoparticle
Magnetic Resonance Imaging - methods
Male
Mice
Mice, Nude
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Oleanolic acid
Oleanolic Acid - chemistry
PET/MRI
Positron-Emission Tomography - methods
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Summary:Abstract Research into multifunctional nanoparticles is focused on creating an agent for use in an all-in-one multimodal imaging system that includes diagnostic imaging, drug delivery, and therapeutic monitoring. We designed a new dual-modality tumor-targeting agent with a new tumor-targeting molecule, oleanolic acid (OA), which is derived from a natural compound and coupled with a macrocyclic chelating agent such as 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), iron oxide nanoparticles (IONP), and radiolabeling components such as68 Ga for dual-modality positron emission tomography (PET)/magnetic resonance imaging (MRI). We attempted to obtain fusion PET/MR images with the68 Ga–NOTA–OA–IONP hybrid tumor-targeting imaging agent using colon cancer (HT-29) xenograft mice models. The HT-29 cancer cells showed high uptake of68 Ga–NOTA–OA–IONP, which also had an inhibitory effect on the cells. Moreover, we obtained PET and MRI tumor images as well as fusion PET/MRI images of the tumors using68 Ga–NOTA–OA–IONP. Therefore, the dual-modality cancer-targeting radiolabeled nanoparticle reported here is a potent imaging agent that is suitable for PET, MRI, and PET/MRI-based diagnosis of tumors; it also has the advantage of not only detecting tumor functionality, but also simultaneously aiding in tumor resolution.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2013.07.078