Effects of Organic Apricot on Liver Regeneration After Partial Hepatectomy in Rats

Abstract Background The present study investigated the effects of (sun-dried organic apricot/SDOA) supplementation in chow on liver regeneration after partial hepatectomy/(PH) in rats. Method In this study, 28 female rats were randomized into four groups. On the 7th day of the study, group 1 underwe...

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Bibliographic Details
Published in:Transplantation proceedings 2013-07, Vol.45 (6), p.2455-2460
Main Authors: Yilmaz, İ, Karaman, A, Vardi, N, Cetin, A, Erdemli, E
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
Cell Proliferation - drug effects
Female
Fruit
Hepatectomy - methods
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver - physiopathology
Liver Regeneration - drug effects
Models, Animal
Organic Agriculture
Oxidative Stress - drug effects
Phytotherapy
Plant Extracts - pharmacology
Plants, Medicinal
Prunus
Rats
Rats, Sprague-Dawley
Surgery
Time Factors
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Summary:Abstract Background The present study investigated the effects of (sun-dried organic apricot/SDOA) supplementation in chow on liver regeneration after partial hepatectomy/(PH) in rats. Method In this study, 28 female rats were randomized into four groups. On the 7th day of the study, group 1 underwent laparoscopic intervention while a PH was performed on the other three cohorts. On day 28, all rats were humanely killed. Blood and liver tissue samples were subjected to biochemical determinations, histological examinations, and measurement of tissue oxidative stress enzyme activity. Results Serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP), and liver tissue glutathione (GSH) activities were affected by PH and/or SDOA consumption ( P  < .05). Moderately staining cell counts in group 4 were significantly different from the other three groups ( P  < .05). However, no significant differences were detected among all groups in regard to aspartate aminotransferase (AST) serum levels or liver tissue superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT) or glutathione peroxidase (GSHpx) activities ( P  < .05). Conclusion The 5% SDOA supplementation over a 21-day feeding period showed a beneficial effect on liver regeneration in rats, as reflects by Ki-67 finding although there was no change in ALT or ALP or in liver tissue GSH activity.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2013.04.005