Identification of the Effects of Aging-Related Gene-Matrix Metalloproteinase on Allograft Outcomes in Kidney Transplantation

Abstract Background Aging plays a profound role in the ability of the kidney to function. Aging which varies among individuals, has been associated with the matrix metalloproteinase (MMP) 7 and 20 genes. This study was conducted to analyze correlations between polymorphisms of MMP genes [rs880197 in...

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Bibliographic Details
Published in:Transplantation proceedings 2013-07, Vol.45 (6), p.2158-2164
Main Authors: Han, S.S, Lee, H, Oh, Y.J, Lee, J.P, Kim, S, Ha, J, Kim, S.J, Park, M.H, Kim, Y.S, Kim, D.K
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aging - genetics
Female
Gene Frequency
Genotype
Graft Survival - genetics
Humans
Kidney Transplantation - adverse effects
Male
Matrix Metalloproteinase 20 - genetics
Matrix Metalloproteinase 7 - genetics
Middle Aged
Phenotype
Polymorphism, Genetic
Risk Factors
Surgery
Time Factors
Treatment Outcome
Young Adult
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Summary:Abstract Background Aging plays a profound role in the ability of the kidney to function. Aging which varies among individuals, has been associated with the matrix metalloproteinase (MMP) 7 and 20 genes. This study was conducted to analyze correlations between polymorphisms of MMP genes [rs880197 in MMP7 (A>T) and rs1711437 in MMP20 (G>A)] and transplant outcomes in 235 recipients. Methods Transplant outcomes were evaluated according to the sum of the A alleles in the recipients and the donors. The group with a high number of A alleles (≥3) was compared with the group with a low number (1 year ( P  = .022). Conclusions Polymorphisms of MMP7 and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2013.03.020