Increased expression of TBX2 is a novel independent prognostic biomarker of a worse outcome in colorectal cancer patients after curative surgery and a potential therapeutic target

T-box2 (TBX2) plays a critical role in embryonic development. Recently, deregulated expression of TBX2 has been implicated in several malignancies. However, the expression and the role of TBX2 in colorectal cancer (CRC) remain unclear. In this study, we found that TBX2 was obviously up-regulated in...

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Published in:Medical oncology (Northwood, London, England) London, England), 2013-12, Vol.30 (4), p.688-688, Article 688
Main Authors: Han, Yang, Tu, Wei-Wei, Wen, Yu-Gang, Yan, Dong-Wang, Qiu, Guo-Qiang, Peng, Zhi-Hai, Zhou, Chong-Zhi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Female
Hematology
Humans
Internal Medicine
Intestinal Mucosa - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Oncology
Original Paper
Pathology
Prognosis
Survival Analysis
T-Box Domain Proteins - biosynthesis
T-Box Domain Proteins - genetics
Transcription, Genetic
Up-Regulation
Young Adult
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Summary:T-box2 (TBX2) plays a critical role in embryonic development. Recently, deregulated expression of TBX2 has been implicated in several malignancies. However, the expression and the role of TBX2 in colorectal cancer (CRC) remain unclear. In this study, we found that TBX2 was obviously up-regulated in CRC in comparison with the corresponding normal mucosa at transcriptional and protein level. Up-expression of TBX2 was significantly associated with depth of tumor invasion ( P  = 0.006), distant metastasis ( P  = 0.038), advanced AJCC stage ( P  = 0.008), and relapse ( P  = 0.003). TBX2 was a significantly prognostic factor for decreased survival and increased disease recurrence independent of tumor stage(II, III stage) and functioned as a biomarker to identify prognosis of patients with CRC (OS: HR 2.154; 95 % CI 1.019–4.551; P  = 0.044, DFS: HR 2.253; 95 % CI 1.109–4.575; P  = 0.025). Furthermore, TBX2 could serve as a potential target of cancer drug therapy.
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-013-0688-3