Determination of age-related liver stiffness changes in rats according to the ultrasonic shear wave elastography

We examined by ultrasound shear wave elastography (SWE) changes of liver stiffness (LS) in three groups rats of different ages. LS measurement by SWE was performed on "Ultima PA" equipment ("Radmir", Kharkov, Ukraine) with a 10-5 MHz linear transducer. To assess the functional st...

Full description

Saved in:
Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2013, Vol.59 (3), p.111-118
Main Authors: Dynnyk, O B, Berezovskyĭ, V Ia, Kobyliak, N M, Litovka, I H, Ianko, R V, Plotnikova, L M
Format: Article
Language:eng ; ukr
Subjects:
Age Factors
Alanine Transaminase - metabolism
Animals
Aspartate Aminotransferases - metabolism
Bilirubin - metabolism
Cell Count
Elasticity
Elasticity Imaging Techniques - instrumentation
Elasticity Imaging Techniques - methods
Female
Hepatocytes - metabolism
Hepatocytes - pathology
Liver - chemistry
Liver - pathology
Male
Rats
Sound
Triglycerides - metabolism
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We examined by ultrasound shear wave elastography (SWE) changes of liver stiffness (LS) in three groups rats of different ages. LS measurement by SWE was performed on "Ultima PA" equipment ("Radmir", Kharkov, Ukraine) with a 10-5 MHz linear transducer. To assess the functional state of the liver at the same time we studied age-related biochemical and morphological differences in the liver. A valid LS determination (success rate of at least 60%) was observed in 96.6% animals of different age groups. We observed statistically significant increasing of LS between 3-month and 20-month rats (p = 0.010), but its value in each group do not exceed normal or reference range. In article discussed possible connection between age-related changes of LS and state of connective tissue elements, functional activity, hydration, etc. It is concluded that shear wave elastography may be a new objective biophysical method for obtaining information about the state of the liver stiffness of the liver tissue.
ISSN:2522-9028
2522-9036
DOI:10.15407/fz59.03.111