Pseudolymphomatous cutaneous angiosarcoma: a report of 2 new cases arising in an unusual setting

Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2013-09, Vol.40 (9), p.848-854
Main Authors: Rongioletti, Franco, Albertini, Ann‐Flore, Fausti, Valentina, Cinotti, Elisa, Parodi, Aurora, Fraitag, Silvie
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antigens, CD34 - metabolism
collision tumor
cutaneous angiosarcoma
Female
Hemangiosarcoma - metabolism
Hemangiosarcoma - pathology
Hemangiosarcoma - therapy
Humans
Lymphocytes - metabolism
Lymphocytes - pathology
Male
Neoplasm Proteins - metabolism
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Skin Neoplasms - therapy
vascular neoplasm
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Summary:Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte‐rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T‐cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2‐40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.12166