Methylation profile of INK4B-ARF-INK4A locus in atherosclerosis

Single-nucleotide polymorphisms (SNPs) in the 9p21.3 locus have recently been demonstrated to be strongly associated with atherosclerosis. However, the pathophysiology of this locus is insufficiently studied. Here, the methylation profile of the nearest mapped genes for cyclin-dependent kinase inhib...

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Bibliographic Details
Published in:Russian journal of genetics 2013-06, Vol.49 (6), p.681-684
Main Authors: Nazarenko, M. S., Markov, A. V., Lebedev, I. N., Sleptsov, A. A., Koroleva, J. A., Frolov, A. V., Barbarash, O. L., Barbarash, L. S., Puzirev, V. P.
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Human Genetics
Microbial Genetics and Genomics
Short Communication
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Summary:Single-nucleotide polymorphisms (SNPs) in the 9p21.3 locus have recently been demonstrated to be strongly associated with atherosclerosis. However, the pathophysiology of this locus is insufficiently studied. Here, the methylation profile of the nearest mapped genes for cyclin-dependent kinase inhibitors CDKN2A (p16 INK4a , p14 ARF ) and CDKN2B (p15 INK4b ) in the tissues of the carotid artery in patients with atherosclerosis was evaluated for the first time. Aberrant DNA methylation of the analyzed loci was not established in either the atherosclerotic plaques or in the tissues from the macroscopically intact vascular wall in the same patients.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795413060070