Peculiarities of phosphoglycerate kinase-1 pseudogene evolution in Schrenck salamander (Salamandrella schrenckii Strauch 1870)

Processed copies of genes generally evolve in neutral mode as pseudogenes, however, some of them might be important sources of new functional genes. The ψ PGK1 pseudogene has been discovered in Schrenck salamander ( Salamandrella schrenckii , Amphibia, Caudata, Hynobiidae) via polymerase chain react...

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Bibliographic Details
Published in:Russian journal of genetics 2013-07, Vol.49 (7), p.722-729
Main Authors: Malyarchuk, B. A., Denisova, G. A., Derenko, M. V.
Format: Article
Language:English
Subjects:
Amphibia
Animal Genetics
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Caudata
Human Genetics
Hynobiidae
Microbial Genetics and Genomics
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Summary:Processed copies of genes generally evolve in neutral mode as pseudogenes, however, some of them might be important sources of new functional genes. The ψ PGK1 pseudogene has been discovered in Schrenck salamander ( Salamandrella schrenckii , Amphibia, Caudata, Hynobiidae) via polymerase chain reaction used to amplify the phosphoglycerate kinase 1 gene ( PGK1 ). This pseudogene is an intronless copy of PGK1 gene absent of exon 6. Analysis of ψ PGK1 pseudogene polymorphism has demonstrated that it lacks mutations, which results in shifts in the stop codons and reading frames, as well as that the interspecies variation of this pseudogene was inconsistent with the neutral model of evolution. In addition, the pattern of phylogeographic differentiation of the ψ PGK1 variants mainly coincides with that observed in mitochondrial DNA. These observations allow it to be suggested that the ψ PGK1 pseudogene is a new functional gene in the Schrenck salamander.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795413070107