Protective Effect of Phenolic-Rich Extracts from Different Parts of Opuntia joconostle Fruit against Carbon Tetrachloride-Induced Oxidative Stress in Mice

The objective of this research was to evaluate the effect of supplementation polyphenols-rich extracts from different parts of Opuntia joconostle against carbon tetrachloride-induced oxidative stress in a mouse model. The animals were treated orally with polyphenols-rich extracts at 50, 100 and 200...

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Bibliographic Details
Published in:Journal of biomaterials and nanobiotechnology 2013-06, Vol.4 (sepcial issue), p.35-35
Main Authors: Osorio-Esquivel, Obed, Ortiz-Moreno, Alicia, Herrera-Martinez, Julieta, Hernandez-Navarro, Maria Dolores
Format: Article
Language:English
Subjects:
Opuntia
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Summary:The objective of this research was to evaluate the effect of supplementation polyphenols-rich extracts from different parts of Opuntia joconostle against carbon tetrachloride-induced oxidative stress in a mouse model. The animals were treated orally with polyphenols-rich extracts at 50, 100 and 200 mg/kg BW for 30 consecutive days. Biochemical evaluations were carried out 24 h after induction of the oxidative stress. Data showed that methanolic extracts from different parts of Opuntia joconostle exerting protective effect against the CC1 sub( 4)-induced oxidative stress in mice. Histology examination revealed that the damage decreased in groups treated with polyphenols-rich extracts compared to the group that did not receive any treatment. Opuntia joconostle fruit contains many phenolic compounds, flavonoids and betalains. The protective effect of extracts may be related to the phenolic composition and also by a counteraction with other compounds, such as betalains and flavonoids that increase their antioxidant effect.
ISSN:2158-7027
2158-7043