Comparison of the Effects of One and Three Sessions of Moderate Hypobaric Hypoxia on Thioredoxin-1 Expression in the Rat Hippocampus

Our previous results from studies of thioredoxin-1 (Trx-1) expression in various parts of the hippocampus 3 and 24 h after three sessions of moderate hypoxia were compared with expression at the same times after single sessions of hypoxia. One and three episodes of moderate hypobaric hypoxia were fo...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2013-05, Vol.43 (4), p.497-501
Main Authors: Stroev, S. A., Tyulkova, E. I., Samoilov, M. O., Pelto-Huikko, M. T.
Format: Article
Language:English
Subjects:
Antioxidants
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Brain
Hypoxia
Neurobiology
Neurons
Neurosciences
Physiology
Variance analysis
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Summary:Our previous results from studies of thioredoxin-1 (Trx-1) expression in various parts of the hippocampus 3 and 24 h after three sessions of moderate hypoxia were compared with expression at the same times after single sessions of hypoxia. One and three episodes of moderate hypobaric hypoxia were found to have similar effects on Trx-1 expression. The observation that the neuroprotective effects after subsequent severe acute hypobaric hypoxia were significantly different suggested that the state of hypoxic tolerance of neurons is not determined by the “baseline” level of antioxidant expression itself, but that more complex mechanisms may operate. These mechanisms may be associated with the wavelike oscillations in Trx-1 expression during preconditioning seen here.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-013-9761-9