Current Concepts of Neurocytoprotective Therapy

This review addressed the pharmacological effects and clinical efficacies of one of the “oldest” neurocytoprotective agents – Cerebrolysin. Experimental data identifying the molecular mechanisms of action of this agent are described in detail, along with results from clinical trials demonstrating th...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2013-03, Vol.43 (3), p.374-379
Main Authors: Gomazkov, O. A., Afanasiev, V. V., Rumyantseva, S. A., Stupin, V. A., Silina, E. V., Sokhova, O. A.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amino acids
Apoptosis
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Clinical medicine
Clinical trials
Dementia
Disease
Family physicians
Homeostasis
Hypertension
Hypoxia
Ischemia
Neurobiology
Neuropeptides
Neurosciences
Peptides
Stroke
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Summary:This review addressed the pharmacological effects and clinical efficacies of one of the “oldest” neurocytoprotective agents – Cerebrolysin. Experimental data identifying the molecular mechanisms of action of this agent are described in detail, along with results from clinical trials demonstrating the efficacy of Cerebrolysin in the treatment of acute and chronic cerebral ischemia, Alzheimer’s disease, and moderate and mild cognitive disorders. It is concluded that Cerebrolysin is an effective agent as demonstrated from the point of view of basic research (including in animal models and cell cultures) and numerous clinical trials in a variety of pathological states.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-013-9743-y