Induction of Morphological Resistance of Neurons to β-Amyloid

• Published in: Neuroscience and behavioral physiology 2013, Vol.43 (1), p.17-21
• Main Authors: Kokanova, N. A., Mikhailova, G. Z., Shtanchaev, R. Sh, Tiras, N. R., Moshkov, and D. A.
• Format: Article
• Language: English
• Subjects: Adaptations; Behavioral Sciences; Biomedical and Life Sciences; Biomedicine; Carassius auratus; Neurobiology; Neurosciences
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/s11055-012-9685-9

The effects of training with adaptive vestibular stimulation on the function and three-dimensional structure of Mauthner neurons (MN) were studied in goldfish with experimental amyloidosis induced by application of aggregated β-amyloid protein (Aβ 25–35 ). In comparison with controls, adapted MN acquired significant resistance to Aβ 25–35 . Considering the key role of dopamine in the adaptation of MN to sensory stimuli, its actions on the development of an amyloidosis model were studied; the results showed that application of dopamine to MN, like increases in the dopamine concentration induced by L-DOPA, was followed by protection of MN structure and function from the pathogenic actions of Aβ 25–35 . Electron microscopic studies showed that the protective action of dopamine on neurons can be explained in terms of its ability to dissociate β-amyloid polymers into short inactive fragments.