Giant-cell glioblastoma of childhood associated with HIV-1 and JC virus coinfection

Purpose John Cunningham (JC) viral DNA sequence has seldom been reported in patients with brain tumors such as high grade gliomas and medulloblastomas, pointing to a role in the etiopathogenesis of such tumors. Results We present a unique clinical case of an HIV-positive pediatric patient with multi...

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Bibliographic Details
Published in:Child's nervous system 2013-08, Vol.29 (8), p.1387-1390
Main Authors: Brassesco, María Sol, Darrigo, Luiz Guilherme, Valera, Elvis Terci, Oliveira, Ricardo Santos, Yamamoto, Yulie Aparecida, de Castro Barros, Marcus Vinícius, Tone, Luiz Gonzaga
Format: Article
Language:English
Subjects:
Adolescent
Brain Neoplasms - etiology
Brain Neoplasms - virology
Case Report
Female
Glioblastoma - etiology
Glioblastoma - virology
HIV Infections - complications
Human immunodeficiency virus 1
Humans
JC virus
JC Virus - genetics
JC Virus - pathogenicity
Karyotype
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Neurosciences
Neurosurgery
Polyomavirus Infections - complications
Viral Matrix Proteins - metabolism
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Summary:Purpose John Cunningham (JC) viral DNA sequence has seldom been reported in patients with brain tumors such as high grade gliomas and medulloblastomas, pointing to a role in the etiopathogenesis of such tumors. Results We present a unique clinical case of an HIV-positive pediatric patient with multifocal leukoencephalopathy and confirmed JC virus (JCV) infection that developed a giant-cell glioblastoma. Conclusions Experimental data with infected primates has previously hypothesized an association of human giant-cell glioblastoma with JCV or progressive multifocal leukoencephalopathy, though such association has not been documented in the literature for humans. Future studies with larger cohorts and molecular pathological analyses are still needed to corroborate the role of the widely spread human neurotropic virus in early transformation and in the development of brain tumors with different histology in the setting of HIV-related severe immunosuppression.
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-013-2154-0