Acidic lactate sequentially induced lymphogenesis, phlebogenesis, and arteriogenesis (ALPHA) hypothesis: Lactate-triggered glycolytic vasculogenesis that occurs in normoxia or hypoxia and complements the traditional concept of hypoxia-based vasculogenesis

Our hypothesis, ALPHA (Acidic Lactate sequentially induced Lymphogenesis, PHlebogenesis, and Arteriogenesis) proposes that lactate triggers vasculogenesis to manage lactate levels and complements the traditional vasculogenesis hypothesis. The teleologic basis for glycolytic vasculogenesis is primari...

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Bibliographic Details
Published in:Surgery 2013-09, Vol.154 (3), p.632-637
Main Authors: Haaga, John R., MD, FACR, FSIR, Haaga, Rebecca, SMT
Format: Article
Language:English
Subjects:
Fibroblast Growth Factor 2 - physiology
Glycolysis
Humans
Hypoxia - physiopathology
Hypoxia-Inducible Factor 1, alpha Subunit - physiology
Lactic Acid - metabolism
Lymphangiogenesis - physiology
Neovascularization, Pathologic - etiology
Neovascularization, Physiologic - physiology
Surgery
Vascular Endothelial Growth Factor A - physiology
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Summary:Our hypothesis, ALPHA (Acidic Lactate sequentially induced Lymphogenesis, PHlebogenesis, and Arteriogenesis) proposes that lactate triggers vasculogenesis to manage lactate levels and complements the traditional vasculogenesis hypothesis. The teleologic basis for glycolytic vasculogenesis is primariy to produce drainage vessels, initially lymphatics but subsequently veins.
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2013.03.007