A comparative analysis of serologic parameters and oxidative stress in osteoarthritis and rheumatoid arthritis: reply to Mishra and colleagues

In chronic diseases such as rheumatoid arthritis and osteoarthritis, the progression of the disease is characterized by stress oxidative, inflammation, and elevated levels of cholesterol. In mevalonate kinase deficiency, an auto-inflammatory disease, the correlation between inflammation and choleste...

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Bibliographic Details
Published in:Rheumatology international 2013-09, Vol.33 (9), p.2445-2446
Main Authors: Girardelli, M., Bianco, A. M., Marcuzzi, A., Crovella, S.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - blood
Female
Humans
Inflammation Mediators - blood
Letter to the Editor
Lipids - blood
Male
Medicine
Medicine & Public Health
Osteoarthritis - blood
Oxidative Stress
Rheumatology
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Summary:In chronic diseases such as rheumatoid arthritis and osteoarthritis, the progression of the disease is characterized by stress oxidative, inflammation, and elevated levels of cholesterol. In mevalonate kinase deficiency, an auto-inflammatory disease, the correlation between inflammation and cholesterol levels is opposite. The metabolic pathway that underlies the production of cholesterol is the mevalonate pathway; it is also essential for the biosynthesis of isoprenoids involved in the control of several cell functions. This divergence of cholesterol levels, associated with these two inflammatory disorders, is probably due to a different etiology, pathogenesis, and progression.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-012-2436-y