Human breast and melanoma cancer stem cells biomarkers

Abstract Cancer progression in humans is difficult to infer because we do not routinely sample patients at multiple stages of their disease. The identification cancer stem cell (CSC) subpopulations inside tumor opens a new view of cancer development, since it implies that tumors can only be eradicat...

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Bibliographic Details
Published in:Cancer letters 2013-09, Vol.338 (1), p.69-73
Main Authors: La Porta, Caterina A.M, Zapperi, Stefano
Format: Article
Language:English
Subjects:
AC133 Antigen
Antigens, CD - metabolism
Biomarkers
Biomarkers, Tumor - metabolism
Bone marrow
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer stem cells
Cell division
Computational analysis
Cytokines
Female
Gene expression
Glycoproteins - metabolism
Hematology, Oncology and Palliative Medicine
Homeostasis
Humans
Hyaluronan Receptors - metabolism
Mathematical models
Melanoma
Melanoma - metabolism
Melanoma - pathology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Octamer Transcription Factor-3 - metabolism
Peptides - metabolism
Population
Receptors, Chemokine - metabolism
Receptors, CXCR6
Receptors, Virus - metabolism
Stem cells
Tumors
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Summary:Abstract Cancer progression in humans is difficult to infer because we do not routinely sample patients at multiple stages of their disease. The identification cancer stem cell (CSC) subpopulations inside tumor opens a new view of cancer development, since it implies that tumors can only be eradicated by targeting CSCs. Several markers have been proposed in the literature to identify CSCs both in breast and melanoma but no consensus has been reached, leading to the hypothesis that the CSC phenotype might be dynamically switched. Herein we provide a critical discussion of the biological markers described in the literature for breast cancer and melanoma. Due to its complexity the field would benefit from an interdisciplinary approach to investigate tumor heterogeneity and its progression. Similar considerations could also be relevant for normal tissue stem cells.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.03.017