Association of clinical features of bone and joint lesions between children and parents with Kashin–Beck disease in Northwest China

• Published in: Clinical rheumatology 2013-09, Vol.32 (9), p.1309-1316
• Main Authors: Cao, Chun-xia, Zhang, Yin-gang, Wu, Shi-xun, Younas, Mohammad Imran, Guo, Xiong
• Format: Article
• Language: English
• Subjects: Adolescent; Cartilage - physiopathology; Child; Child, Preschool; China; Female; Finger Phalanges - diagnostic imaging; Humans; Kashin-Beck Disease - diagnosis; Kashin-Beck Disease - diagnostic imaging; Kashin-Beck Disease - epidemiology; Male; Medicine; Medicine & Public Health; Odds Ratio; Original Article; Parents; Prevalence; Radiography; Rheumatology; Surveys and Questionnaires
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-013-2267-6

We investigated the clinical features of bone and joint lesions in children with Kashin–Beck disease (KBD) and the association of these features with their parents to determine specific clinical features for diagnosing KBD. A total of 2,248 children (4 to 18 years old) and their parents were examined by stratified cluster sampling from 33 villages in six endemic counties and from six villages in a non-endemic county. We collected individual information, clinical symptoms, and radiological signs of the right hand. KBD in children and their parents was assessed using the “Diagnosis Criteria of Kashin–Beck disease in China (WS/T207-2010).” Univariate and multivariate analyses were used to examine the correlation of clinical features between parents and offspring with KBD. The rates of clinical features in children were correlated with those in parents ( P