A Walnut-Enriched Diet Reduces the Growth of LNCaP Human Prostate Cancer Xenografts in Nude Mice

It was investigated whether a standard mouse diet (AIN-76A) supplemented with walnuts reduced the establishment and growth of LNCaP human prostate cancer cells in nude (nu/nu) mice. The walnut-enriched diet reduced the number of tumors and the growth of the LNCaP xenografts; 3 of 16 (18.7%) of the w...

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Bibliographic Details
Published in:Cancer investigation 2013-07, Vol.31 (6), p.365-373
Main Authors: Reiter, Russel J., Tan, Dun-Xian, Manchester, Lucien C., Korkmaz, Ahmet, Fuentes-Broto, Lorena, Hardman, W. Elaine, Rosales-Corral, Sergio A., Qi, Wenbo
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Animals
Antineoplastic agents
Antineoplastic Agents, Phytogenic - administration & dosage
Biological and medical sciences
Causation and Prevention
Cell Line, Tumor
F2-Isoprostanes - metabolism
Gynecology. Andrology. Obstetrics
Humans
isoprostanes
Juglans
Lipid Peroxidation
Liver - metabolism
LNCaP cells
Male
Male genital diseases
Medical sciences
Mice
Mice, Nude
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Nephrology. Urinary tract diseases
Oxidative Stress
Pharmacology. Drug treatments
Phytotherapy
Plant Preparations - administration & dosage
Prostate cancer
Prostate-Specific Antigen - metabolism
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Tumor Burden
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
Walnuts
Xenograft Model Antitumor Assays
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Summary:It was investigated whether a standard mouse diet (AIN-76A) supplemented with walnuts reduced the establishment and growth of LNCaP human prostate cancer cells in nude (nu/nu) mice. The walnut-enriched diet reduced the number of tumors and the growth of the LNCaP xenografts; 3 of 16 (18.7%) of the walnut-fed mice developed tumors; conversely, 14 of 32 mice (44.0%) of the control diet-fed animals developed tumors. Similarly, the xenografts in the walnut-fed animals grew more slowly than those in the control diet mice. The final average tumor size in the walnut-diet animals was roughly one-fourth the average size of the prostate tumors in the mice that ate the control diet.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2013.800095