Polymorphisms in IL-1 gene cluster and its association with the risk of perinatal HIV transmission, in an Indian cohort

Highlights • CT/CC genotype at IL1R1 (rs2234650) was associated with perinatal HIV transmission. • IL1R1 (rs2234650) was not in linkage disequilibrium with other IL-1 SNPs studied. • TCCCT haplotype was significantly associated with perinatal transmission. • SNPs of IL-1 gene family: possible predic...

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Bibliographic Details
Published in:Immunology letters 2013-06, Vol.153 (1), p.1-8
Main Authors: Ahir, Swati, Chaudhari, Deepali, Chavan, Vijay, Samant-Mavani, Padmaja, Nanavati, Ruchi, Mehta, Preeti, Mania-Pramanik, Jayanti
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Cohort Studies
Cytokine genes
Female
Gene Frequency
Genetic Markers - genetics
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Haplotypes
HIV Infections - drug therapy
HIV Infections - transmission
HIV-1 - immunology
Humans
IL-1 family
India
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
Interleukin-1 - genetics
Interleukin-1 - metabolism
Linkage Disequilibrium - genetics
Multigene Family - genetics
Perinatal HIV
Polymorphism, Single Nucleotide
Receptors, Interleukin-1 - genetics
Receptors, Interleukin-1 - metabolism
Risk
SNPs
Viral Load
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Summary:Highlights • CT/CC genotype at IL1R1 (rs2234650) was associated with perinatal HIV transmission. • IL1R1 (rs2234650) was not in linkage disequilibrium with other IL-1 SNPs studied. • TCCCT haplotype was significantly associated with perinatal transmission. • SNPs of IL-1 gene family: possible predictors of perinatal HIV transmission.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.05.008