Effects of Serum Testosterone Levels After 6 Months of Androgen Deprivation Therapy on the Outcome of Patients With Prostate Cancer

Micro-Abstract Androgen deprivation therapy (ADT) is administered in patients with locally advanced metastatic disease, those with high-risk localized disease, and those with biochemical failure. The goal is to induce a profound drop in plasma testosterone levels. This study confirms that serum test...

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Bibliographic Details
Published in:Clinical genitourinary cancer 2013-09, Vol.11 (3), p.325-330.e1
Main Authors: Bertaglia, Valentina, Tucci, Marcello, Fiori, Cristian, Aroasio, Emiliano, Poggio, Massimiliano, Buttigliero, Consuelo, Grande, Susanna, Saini, Andrea, Porpiglia, Francesco, Berruti, Alfredo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Androgen Antagonists - therapeutic use
Antineoplastic Agents, Hormonal - therapeutic use
Biomarkers - blood
Gonadotropin-Releasing Hormone - analogs & derivatives
Hematology, Oncology and Palliative Medicine
Hormonal therapy
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Prostate cancer
Prostatic Neoplasms - blood
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - mortality
Survival
Testosterone
Testosterone - blood
Treatment Outcome
Urology
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Summary:Micro-Abstract Androgen deprivation therapy (ADT) is administered in patients with locally advanced metastatic disease, those with high-risk localized disease, and those with biochemical failure. The goal is to induce a profound drop in plasma testosterone levels. This study confirms that serum testosterone levels have a prognostic role in patients with prostate cancer receiving ADT. Serum testosterone levels lower than the currently adopted cutoff seem to be associated with prognosis.
ISSN:1558-7673
1938-0682
DOI:10.1016/j.clgc.2013.01.002