LAVENDOMYCIN, A NEW ANTIBIOTIC: I. TAXONOMY, ISOLATION AND CHARACTERIZATION

Lavendomycin, a new basic peptide antibiotic containing novel amino acids, has been isolated from the culture broth of a streptomyces designated as Streptomyces lavendulae subsp. brasilicus. The antibiotic obtained as colorless crystals (C29H50N10O8, MW 666) is active against Gram-positive bacteria...

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Bibliographic Details
Published in:Journal of antibiotics 1985, Vol.38(6), pp.691-698
Main Authors: KOMORI, TADAAKI, EZAKI, MASAMI, KINO, EIKO, KOHSAKA, MASANOBU, AOKI, HATSUO, IMANAKA, HIROSHI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry
Fermentation
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
lavendomycin
Male
Medical sciences
Mice
Mice, Inbred ICR
Peptides - isolation & purification
Pharmacology. Drug treatments
Production of active biomolecules
Streptomyces - classification
Streptomyces - metabolism
Streptomyces lavendulae
Streptomyces lavendulae brasilicus
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Summary:Lavendomycin, a new basic peptide antibiotic containing novel amino acids, has been isolated from the culture broth of a streptomyces designated as Streptomyces lavendulae subsp. brasilicus. The antibiotic obtained as colorless crystals (C29H50N10O8, MW 666) is active against Gram-positive bacteria in vitro and in vivo, however, inactive against Gramnegative bacteria and fungi. An acute toxicity of the antibiotic in mice was LD50>2 g/kg by subcutaneous injection.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.38.691