Use of APTIMA Combo 2: The Experience of a Child Advocacy Center

The Centers for Disease Control and Prevention recommends nucleic acid amplification testing for chlamydia and gonorrhea in sexually abused girls. No studies describe performance of APTIMA Combo 2 Assay with second target confirmation on the same testing platform. This nucleic acid amplification tes...

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Bibliographic Details
Published in:Journal of child sexual abuse 2013-04, Vol.22 (3), p.297-311
Main Authors: Leder, M. Ranee, Leber, Amy L., Marcon, Mario J., Scribano, Philip V.
Format: Article
Language:English
Subjects:
Adolescent
Advocacy
Centers for Disease Control and Prevention (U.S.)
Child
Child Abuse
Child abuse & neglect
Child Abuse, Sexual - diagnosis
Child Advocacy - standards
Child, Preschool
Children
Chlamydia Infections - diagnosis
Chlamydia Infections - microbiology
Chlamydia Infections - urine
Chlamydia trachomatis - pathogenicity
Cultural Sensitivity
Diagnostic Tests
Female
Females
Fisher Exact Probability Test
Girls
Gonorrhea - diagnosis
Gonorrhea - microbiology
Gonorrhea - urine
Health Care Services
Humans
McNemar Test of Equality of Correlated Proportion
Neisseria gonorrhoeae - pathogenicity
Nucleic Acid Amplification Techniques - standards
Participant Characteristics
Prevention
Reagent Kits, Diagnostic - standards
Regression (Statistics)
Sex crimes
Sexual Abuse
Sexual Behavior
sexual victimization
Sexuality
Sexually Transmitted Diseases
sexually transmitted infections
Statistical Analysis
STD
STIs
Trauma
United States
United States (Midwest)
Vagina - microbiology
Vaginal Smears - standards
Venereal Diseases
Victims
Wilcoxon Rank Sum Test
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Description
Summary:The Centers for Disease Control and Prevention recommends nucleic acid amplification testing for chlamydia and gonorrhea in sexually abused girls. No studies describe performance of APTIMA Combo 2 Assay with second target confirmation on the same testing platform. This nucleic acid amplification testing is evaluated within a large child advocacy center. Girls 3 to 18 years, 35% of whom reported consensual sexual activity, were prospectively tested by APTIMA Combo 2 on urine/vaginal swabs and by vaginal culture. A case of infection was defined as positive culture or positive urine or vaginal swab nucleic acid amplification testing with second target confirmation. Sensitivity of APTIMA Combo 2 on urine was found to be superior to vaginal culture and comparable to APTIMA Combo 2 on vaginal swabs for both infections. APTIMA Combo 2 on urine is less invasive, and its use may be preferred in this traumatized population.
ISSN:1053-8712
1547-0679
DOI:10.1080/10538712.2013.743954