Gamma-glutamyl transpeptidase level is a novel adverse prognostic indicator in human metastatic colorectal cancer

Aim Biomarkers have been utilized for prognosis in colorectal cancer; however, relatively few have been identified. We compared the prognostic value of serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma‐glutamyl transpeptidase (GGT) with carcinoembryonic antigen (CEA) and carboh...

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Bibliographic Details
Published in:Colorectal disease 2013-08, Vol.15 (8), p.e443-e452
Main Authors: He, W.-z., Guo, G.-f., Yin, C.-x., Jiang, C., Wang, F., Qiu, H.-j., Chen, X.-x., Rong, R.-m., Zhang, B., Xia, L.-p.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Alkaline Phosphatase - blood
Antigens, Tumor-Associated, Carbohydrate - blood
Antineoplastic Agents - therapeutic use
biomarker
Biomarkers, Tumor - blood
carcinoembryonic antigen
Carcinoembryonic Antigen - blood
colorectal cancer
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - mortality
Female
Gamma-glutamyl transpeptidase
gamma-Glutamyltransferase - blood
Humans
Kaplan-Meier Estimate
L-Lactate Dehydrogenase - blood
Male
Middle Aged
Neoplasm Metastasis - pathology
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
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Summary:Aim Biomarkers have been utilized for prognosis in colorectal cancer; however, relatively few have been identified. We compared the prognostic value of serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma‐glutamyl transpeptidase (GGT) with carcinoembryonic antigen (CEA) and carbohydrate antigen 19‐9 (CA19‐9) in patients with metastatic colorectal cancer (mCRC). Method Blood samples were collected from 239 patients with mCRC presenting between 2005 and 2010 in the Sun Yat‐sen University Cancer Center. Results CEA (P 
ISSN:1462-8910
1463-1318
DOI:10.1111/codi.12258