Dysregulation of angiogenic homeostasis in systemic sclerosis

Background Systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue hypoxia and excessive fibrosis of skin and internal organs. Objective To evaluate the possible role of angiogenesis imbalance in the pathogenesis of SSc. Subjects and methods Twenty‐five SSc patients and 20 a...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2013-08, Vol.16 (4), p.448-454
Main Authors: Farouk, Hanan Mohamed, Hamza, Sherine Hosny, El Bakry, Samah A., Youssef, Sahar S., Aly, Iman Mohamed, Moustafa, Afaf A., Assaf, Naglaa Youssef, El Dakrony, Al Hussein M.
Format: Article
Language:English
Subjects:
Adult
angiogenesis
Biopsy
Case-Control Studies
Disease Progression
endostatin
Endostatins - blood
Endostatins - physiology
Female
Homeostasis - physiology
Humans
Male
Middle Aged
Neovascularization, Physiologic - physiology
Pulmonary Fibrosis - physiopathology
Respiratory Function Tests
Scleroderma, Systemic - etiology
Scleroderma, Systemic - physiopathology
Severity of Illness Index
skin
Skin - pathology
systemic sclerosis
vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor A - physiology
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Summary:Background Systemic sclerosis (SSc) is a connective tissue disorder characterized by tissue hypoxia and excessive fibrosis of skin and internal organs. Objective To evaluate the possible role of angiogenesis imbalance in the pathogenesis of SSc. Subjects and methods Twenty‐five SSc patients and 20 age‐ and sex‐matched healthy controls were included. Assay of serum vascular endothelial growth factor (VEGF) and endostatin was done for all patients and controls using enzyme‐linked immunosorbent assay. Patients were subjected to modified Rodnan skin score (mRss), pulmonary function tests (PFTS) and skin biopsies for histopathological skin thickness score assessment. Results There was significant increase in the mean levels of serum VEGF and endostatin in SSc patients compared to controls (t = 4.07, P 
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.12130