7-HYDROXYGUANINE, A NOVEL ANTIMETABOLITE FROM A STRAIN OF STREPTOMYCES PURPURASCENS: I. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

Strain A-347, an actinomycete isolated from a soil sample, was found to produce a new antimetabolite, 7-hydroxyguanine. The aerial mycelium formed spiral spore chains with spiny spore surface. The chemical composition of strain A-347 indicated that it was an actinomycete of cell wall Type I. From it...

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Bibliographic Details
Published in:Journal of antibiotics 1985, Vol.38(8), pp.972-976
Main Authors: KITAHARA, MIKIO, ISHII, KIYOTO, KUMADA, YOSHIKI, SHIRAISHI, TADAYOSHI, FURUTA, TAKESHI, MIWA, TOSHIAKI, KAWAHARADA, HAJIME, WATANABE, KIYOSHI
Format: Article
Language:English
Subjects:
7-hydroxyguanine
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimetabolites, Antineoplastic - isolation & purification
Antimetabolites, Antineoplastic - pharmacology
Antiviral drugs
Biological and medical sciences
Biotechnology
Fermentation
Fundamental and applied biological sciences. Psychology
Guanine - analogs & derivatives
Guanine - isolation & purification
Guanine - pharmacology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Male
Medical sciences
Mice
Mice, Inbred Strains
Miscellaneous. Antibiotics with multiple activities
Pharmacology. Drug treatments
Production of active biomolecules
Streptomyces - classification
Streptomyces - metabolism
Streptomyces purpurascens
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Summary:Strain A-347, an actinomycete isolated from a soil sample, was found to produce a new antimetabolite, 7-hydroxyguanine. The aerial mycelium formed spiral spore chains with spiny spore surface. The chemical composition of strain A-347 indicated that it was an actinomycete of cell wall Type I. From its morphological, cultural, physiological characteristics and direct comparison with the type culture, this strain was classified as Streptomyces purpurascens. 7-Hydroxyguanine was purified from the broth filtrate by ion exchange chromatography and crystallized from hot 2 M NH4OH. 7-Hydroxyguanine inhibited the growth of experimental tumors such as L1210 leukemia.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.38.972