Prospective validation of quantitative NSE mRNA in pleural fluid of non-small cell lung cancer patients

Although the survival of lung cancer patients has improved significantly due to the development of early detective tools, lung cancer remains a leading cause of cancer-related death after curative surgery. So it is extremely important for cancer patients to predict early metastasis, especially pleur...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2013-12, Vol.30 (4), p.699-699, Article 699
Main Authors: Tang, Dongfang, Wang, Mingzhao, Sui, Aihua, Wang, Yongjie, Yang, Ronghua, Wang, Zizong, Zhao, Yandong, Jiao, Wenjie, Shen, Yi
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Female
Hematology
Humans
Internal Medicine
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Oncology
Original Paper
Pathology
Phosphopyruvate Hydratase - genetics
Pleural Cavity - pathology
Pleural Neoplasms - genetics
Pleural Neoplasms - mortality
Pleural Neoplasms - pathology
Pleural Neoplasms - secondary
Prognosis
Prospective Studies
Retrospective Studies
RNA, Messenger - genetics
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Summary:Although the survival of lung cancer patients has improved significantly due to the development of early detective tools, lung cancer remains a leading cause of cancer-related death after curative surgery. So it is extremely important for cancer patients to predict early metastasis, especially pleural dissemination, the most frequent type of recurrence in patients after surgery. Based on a retrospective study of 86 curatively resected lung cancer patients (training set), we determined a cutoff value of NSE mRNA using receiver-operating characteristic curve. Then, we prospectively used this cutoff value to validate the risk of pleural recurrence in a new cohort of 81 lung cancer patients (validation set) between April 2009 and June 2010 by real-time reverse transcriptase-polymerase chain reaction. During the median 27 months of postoperative surveillance, 16 of the 81 patients died, and 9 of the 16 developed pleural metastases. Multivariate analysis with the Cox proportional hazards model showed that positive NSE mRNA was a significant independent risk factor with both overall survival and pleural recurrence-free survival (both P  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-013-0699-0