Screening Strategies for Hip Dysplasia: Long-term Outcome of a Randomized Controlled Trial

• Published in: Pediatrics (Evanston) 2013-09, Vol.132 (3), p.492-501
• Main Authors: LABORIE, Lene B, ENGESAETER, Ingvild Ø, LEHMANN, Trude G, EASTWOOD, Deborah M, ENGESEATER, Lars B, ROSENDAHL, Karen
• Format: Article
• Language: English
• Subjects: Acetabulum; Adolescent; Biological and medical sciences; Bones; Clinical trials; Cohort Studies; Congenital hip dysplasia; Diagnosis; Diseases of the osteoarticular system; Early Medical Intervention; Female; Femur Head Necrosis - diagnosis; Femur Head Necrosis - epidemiology; Gangrene; General aspects; Hip Dislocation, Congenital - diagnosis; Hip Dislocation, Congenital - epidemiology; Hip Dislocation, Congenital - therapy; Humans; Infant, Newborn; Infants (Newborn); Male; Malformations and congenital and or hereditary diseases involving bones. Joint deformations; Medical examination; Medical sciences; Medical screening; Medical treatment; Necrosis; Neonatal screening; Neonatal Screening - methods; Norway; Orthotic Devices; Osteoarthritis, Hip - diagnosis; Osteoarthritis, Hip - epidemiology; Osteonecrosis; Pediatrics; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Radiography; Teenagers; Tomography, X-Ray Computed; Ultrasonography; Young Adult
• ISSN: 0031-4005; 1098-4275
• DOI: 10.1542/peds.2013-0911

Screening for hip dysplasia is controversial. A previous randomized controlled trial revealed that adding universal or selective ultrasound to routine clinical examination gave a nonsignificant reduction in rates of late presenting cases, but with higher treatment rates. This study assesses differences in outcome at skeletal maturity for the 3 newborn screening strategies in terms of radiographic markers of acetabular dysplasia and early degenerative change and avascular necrosis (AVN) secondary to neonatal treatment. From the initial trial including 11 925 newborns, a population-based sample of 3935 adolescents was invited for follow-up at age 18 to 20 years. A standardized weight-bearing anteroposterior view was obtained. The outcomes evaluated were the radiographic findings of dysplasia (center-edge angle, femoral head extrusion-index, acetabular depth-width ratio, Sharp's angle, subjective evaluation of dysplasia) and degenerative change (joint-space width). Signs of AVN were documented. Of the 3935 subjects invited, 2038 (51.8%) attended the maturity review, of which 2011 (58.2% female patients) were included: 551, 665, and 795 subjects from the universal, selective, and clinical groups, respectively. Rates per group of positive radiographic findings associated with dysplasia or degenerative change varied depending on radiographic marker used. No statistically significant differences were detected between groups. No AVN was seen. Although both selective and universal ultrasound screenings gave a nonsignificant reduction in rates of late cases when compared with expert clinical programs, we were unable to demonstrate any additional reduction in the rates of radiographic findings associated with acetabular dysplasia or degenerative change at maturity. Increased treatment rates were not associated with AVN.