Temperature-dependent THz vibrational spectra of clenbuterol hydrochloride

Using the high-resolution Terahertz Time-domain spectroscopy （THz-TDS） and the standard sample pellet technique, the far-infrared vibrational spectra of clenbuterol hydrochloride （CH）, a 2 -adrenergic agonist for decreasing fat deposition and enhancing protein accretion, were measured in temperature...

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Bibliographic Details
Published in:Science China. Physics, mechanics & astronomy mechanics & astronomy, 2013-04, Vol.56 (4), p.713-717
Main Authors: Yang, YuPing, Lei, XiangYun, Yue, Ai, Zhang, Zhenwei
Format: Article
Language:English
Subjects:
Astronomy
Blue shift
Classical and Continuum Physics
Far infrared radiation
Food safety
Infrared spectra
Line spectra
Observations and Techniques
Physics
Physics and Astronomy
Temperature dependence
THz-TDS
Vibrational spectra
光谱特征
太赫兹时域光谱技术
温度变化
盐酸克伦特罗
红外振动光谱
肾上腺素受体激动剂
食品安全控制
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Summary:Using the high-resolution Terahertz Time-domain spectroscopy （THz-TDS） and the standard sample pellet technique, the far-infrared vibrational spectra of clenbuterol hydrochloride （CH）, a 2 -adrenergic agonist for decreasing fat deposition and enhancing protein accretion, were measured in temperature range of 77–295 K. Between 0.2 and 3.6 THz （6.6–120.0 cm–1 ）, seven highly resolved spectral features, strong line-narrowing and a frequency blue-shift were observed with cooling. However, ractopamine hydrochloride, with some structural and pharmacological similarities to clenbuterol hydrochloride, showed no spectral features, indicating high sensitivity and strong specificity of THz-TDS. These results could be used for the rapid and nondestructive CH residual detection in food safety control.
ISSN:1674-7348
1869-1927
DOI:10.1007/s11433-013-5039-z