Healthcare Cost Reductions Associated with the Use of LAI Formulations of Antipsychotic Medications Versus Oral Among Patients with Schizophrenia

Real-world medication adherence and healthcare costs of patients with schizophrenia initiating long-acting injectable (LAI) vs. oral antipsychotics were compared. Patients with schizophrenia initiating LAI or oral antipsychotics (index event) were identified from MarketScan Commercial and Medicare c...

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Bibliographic Details
Published in:The journal of behavioral health services & research 2013-07, Vol.40 (3), p.355-366
Main Authors: Lin, Jay, Wong, Bruce, Offord, Steve, Mirski, Dario
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Ambulatory Care - economics
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - economics
Antipsychotic Agents - therapeutic use
Antipsychotic drugs
Antipsychotics
Chemistry, Pharmaceutical - economics
Clinical trials
Community and Environmental Psychology
Comorbidity
Cost control
Demographics
Drug therapy
Female
Generalized linear models
Health Care Costs
Health care expenditures
Health costs
Health Informatics
Health maintenance organizations
Health Promotion and Disease Prevention
Health Psychology
Health services
HMOs
Hospital costs
Hospitalization
Humans
Insurance coverage
Male
Medicare
Medicare - economics
Medicine
Medicine & Public Health
Mental health
Middle Aged
Outpatient care facilities
Outpatient treatment
Patient compliance
Patients
Prescription drugs
Psychiatry
Psychotropic drugs
Public Health
Retrospective Studies
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - economics
Studies
United States
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Description
Summary:Real-world medication adherence and healthcare costs of patients with schizophrenia initiating long-acting injectable (LAI) vs. oral antipsychotics were compared. Patients with schizophrenia initiating LAI or oral antipsychotics (index event) were identified from MarketScan Commercial and Medicare claims databases and their medication possession ratios (MPR), pre- and post-index costs for inpatient/outpatient care were compared. Of 3,004 patients, 394 initiated LAI antipsychotics and 2,610 oral antipsychotics. Post-index, the mean MPR was greater for the LAI cohort (0.67 ± 0.34 vs. 0.56 ± 0.35; p  
ISSN:1094-3412
1556-3308
DOI:10.1007/s11414-013-9329-z