Evidence that the Echinococcus granulosus G6 genotype has an affinity for the brain in humans

•Molecular characteristics of human cerebral hydatid cysts were investigated.•BLAST analysis indicated sequenced isolates were Echinococcus granulosus(G6) genotype.•G6 genotype is found more frequently in the brain than other anatomical sites.•G6 has a higher affinity for the human brain than G1 gen...

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Bibliographic Details
Published in:International journal for parasitology 2013-10, Vol.43 (11), p.875-877
Main Authors: Sadjjadi, S.M., Mikaeili, F., Karamian, M., Maraghi, S., Sadjjadi, F.S., Shariat-Torbaghan, S., Kia, E.B.
Format: Article
Language:English
Subjects:
Animals
Brain
Brain - parasitology
Cluster Analysis
DNA
DNA, Helminth - chemistry
DNA, Helminth - genetics
Echinococcosis
Echinococcosis - parasitology
Echinococcus cyst
Echinococcus granulosus
Echinococcus granulosus - classification
Echinococcus granulosus - genetics
Echinococcus granulosus - physiology
G6 genotype
Genotype
Human
Humans
liver
Molecular Sequence Data
Sequence Analysis, DNA
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Summary:•Molecular characteristics of human cerebral hydatid cysts were investigated.•BLAST analysis indicated sequenced isolates were Echinococcus granulosus(G6) genotype.•G6 genotype is found more frequently in the brain than other anatomical sites.•G6 has a higher affinity for the human brain than G1 genotype. The present study investigates the molecular characteristics of cerebral Echinococcus cysts. A total of 10 specimens of cerebral Echinococcus cysts, including six formalin-fixed paraffin blocks and four intact cerebral cysts, were used for this study. The target DNA was successfully amplified from eight samples and sequenced. BLAST analysis indicated that sequenced isolates belong to the Echinococcus granulosus (G6) genotype. All of the eight sampled brain cysts belonged to the G6 genotype, while all of the eight liver cysts belonged to G1. This is a strong indication that G6 has a higher affinity for the human brain than G1.
ISSN:0020-7519
1879-0135
DOI:10.1016/j.ijpara.2013.06.008