Formulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure

The aim of the study was to develop and evaluate a self--emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in variou...

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Bibliographic Details
Published in:Acta pharmaceutica (Zagreb, Croatia) Croatia), 2012-12, Vol.62 (4), p.563-580
Main Authors: Meena, Ashok K, Sharma, Kuldeep, Kandaswamy, Murugesh, Rajagopal, Sriram, Mullangi, Ramesh
Format: Article
Language:English
Subjects:
Administration, Oral
Albendazole - administration & dosage
Albendazole - analysis
Albendazole - pharmacokinetics
Animals
Anthelmintics - administration & dosage
Anthelmintics - analysis
Anthelmintics - pharmacokinetics
Biological Availability
Chemistry, Pharmaceutical - methods
Drug Delivery Systems - methods
Emulsifying Agents - administration & dosage
Emulsifying Agents - analysis
Male
Oils - administration & dosage
Oils - analysis
Particle Size
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - analysis
Polysorbates - administration & dosage
Polysorbates - analysis
Rats
Solubility
Surface-Active Agents - administration & dosage
Surface-Active Agents - analysis
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Summary:The aim of the study was to develop and evaluate a self--emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in various oils, surfactants and co-surfactants to identify the microemulsion components. Pseudoternary phase diagrams were plotted to identify the microemulsification existence area. SEDDS formulation of ABZ was prepared using oil (Labrafac Lipopfile WL1349) and a surfactant/co-surfactant (Tween 80/PEG 400) mixture and was characterized by appropriate studies, viz., microemulsifying properties, droplet size measurement, in vitro dissolution, etc. Finally, PK of the ABZ SEDDS formulation was performed on rats in parallel with suspension formulation. It was concluded that the SEDDS formulation approach can be used to improve the dissolution and systemic exposure of poorly water-soluble drugs such as ABZ.
ISSN:1846-9558
DOI:10.2478/v10007-012-0031-0