Proliferative Lesions Found in Rat Kidneys After a Single Dose of Cisplatin

Proliferative lesions in inbred F344 rat kidneys were studied at 6 and 15 months after a Single injection of 6 mg cisplatin [CAS: 15663-27-1; cis-diamminedichloroplatinum (II)]/kg body weight. Solid or cystic lesions developed from altered proximal tubular epithelial cells. The lesions affecting the...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1984-11, Vol.73 (5), p.1235-1242
Main Authors: Bulger, Ruth Ellen, Dobyan, Dennis C.
Format: Article
Language:English
Subjects:
Animals
Cell Division - drug effects
Cisplatin - toxicity
Kidney - drug effects
Kidney - pathology
Kidney - ultrastructure
Male
Microscopy, Electron
Rats
Rats, Inbred F344
Time Factors
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Summary:Proliferative lesions in inbred F344 rat kidneys were studied at 6 and 15 months after a Single injection of 6 mg cisplatin [CAS: 15663-27-1; cis-diamminedichloroplatinum (II)]/kg body weight. Solid or cystic lesions developed from altered proximal tubular epithelial cells. The lesions affecting the renal proximal tubules had both granular (organelle-rich) and clear (organelle-poor) variants. These altered cells retained microvilli and contained numerous lysosomes, mitochondria, and abundant rough-surfaced endoplasmic reticulum and free ribosomes. In addition, papillary hyperplasia was seen at 15 months and involved the epithelium lining the renal papilla. The hyperplastic changes of the papillary epithelium were morphologicaly similar to those produced by other drugs.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/73.5.1235