Autoantibodies to Neuron-Specific Proteins S100, GFAP, MBP and NGF in the Serum of Rats with Streptozotocin-Induced Diabetes

The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-05, Vol.155 (1), p.48-51
Main Authors: Lotosh, N. G., Savel’eva, E. K., Selishcheva, A. A., Savel’ev, S. V.
Format: Article
Language:English
Subjects:
Animals
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Autoimmunity
Biomedical and Life Sciences
Biomedicine
Blood Glucose
Blood sugar
Blood-Brain Barrier - metabolism
Brain - immunology
Cell Biology
Diabetes Mellitus, Experimental - immunology
Enzyme-linked immunosorbent assay
Glial Fibrillary Acidic Protein - immunology
Glucose metabolism
Insulin - immunology
Intermediate filament proteins
Internal Medicine
Laboratory Medicine
Male
Myelin Basic Protein - immunology
Nerve growth factor
Nerve Growth Factor - immunology
Nerve Tissue Proteins - immunology
Neurons
Pathology
Rats
Rats, Wistar
S100 Proteins - immunology
Streptozocin
Type 1 diabetes
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Summary:The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin injection and the level of autoantibodies to insulin significantly increased on day 5 indicating the development of diabetes. The levels of antibodies to specific neuronal proteins (S100, GFAP, MBP, and NGF) also increased at this term. It is concluded that diabetes with streptozotocin is associated with damage to the blood-brain barrier.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2077-5