Rare manifestation of the thrombotic microangiopathy in a patient with sarcoidosis, common variable immunodeficiency and large B-cell non-hodgkin lymphoma: Case report

Abstract 58-year old Caucasian woman was diagnosed with sarcoidosis. Low immunoglobulin levels were found and common variable immunodeficiency (CVID) was diagnosed 1 year later. Laboratory tests and clinical course at this time revealed thrombotic microangiopathy (TMA). Therapeutic plasma exchange w...

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Bibliographic Details
Published in:Transfusion and apheresis science 2013-06, Vol.48 (3), p.345-347
Main Authors: Ekart, Robert, Grobelšek, Vesna Kovačič, Dai, Klara, Černelč, Peter, Hojs, Radovan
Format: Article
Language:English
Subjects:
B-cell non-Hodgkin lymphoma
Common variable immunodeficiency
Common Variable Immunodeficiency - complications
Common Variable Immunodeficiency - diagnosis
Female
Health technology assessment
Hematology, Oncology and Palliative Medicine
Humans
Immunoglobulins, Intravenous - therapeutic use
Lymphatic Diseases
Lymphoma, Large B-Cell, Diffuse - complications
Lymphoma, Large B-Cell, Diffuse - diagnosis
Middle Aged
Parotid Gland - pathology
Risk
Sarcoidosis
Sarcoidosis - complications
Sarcoidosis - diagnosis
Thrombotic Microangiopathies - complications
Thrombotic Microangiopathies - diagnosis
Thrombotic microangiopathy
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Summary:Abstract 58-year old Caucasian woman was diagnosed with sarcoidosis. Low immunoglobulin levels were found and common variable immunodeficiency (CVID) was diagnosed 1 year later. Laboratory tests and clinical course at this time revealed thrombotic microangiopathy (TMA). Therapeutic plasma exchange was started and her clinical status and laboratory parameters improved. According to CVID she received human immunoglobulin intravenously. Four months later we noticed swelling of the parotid glands and generalized lymphadenopathy. Histology of cervical lymph node confirmed large B-cell non-Hodgkin lymphoma (B-cell NHL). To the best of our knowledge, TMA complicating the course of sarcoidosis, CVID and B-cell NHL has never been reported.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2013.04.014