Rare manifestation of the thrombotic microangiopathy in a patient with sarcoidosis, common variable immunodeficiency and large B-cell non-hodgkin lymphoma: Case report

• Published in: Transfusion and apheresis science 2013-06, Vol.48 (3), p.345-347
• Main Authors: Ekart, Robert, Grobelšek, Vesna Kovačič, Dai, Klara, Černelč, Peter, Hojs, Radovan
• Format: Article
• Language: English
• Subjects: B-cell non-Hodgkin lymphoma; Common variable immunodeficiency; Common Variable Immunodeficiency - complications; Common Variable Immunodeficiency - diagnosis; Female; Health technology assessment; Hematology, Oncology and Palliative Medicine; Humans; Immunoglobulins, Intravenous - therapeutic use; Lymphatic Diseases; Lymphoma, Large B-Cell, Diffuse - complications; Lymphoma, Large B-Cell, Diffuse - diagnosis; Middle Aged; Parotid Gland - pathology; Risk; Sarcoidosis; Sarcoidosis - complications; Sarcoidosis - diagnosis; Thrombotic Microangiopathies - complications; Thrombotic Microangiopathies - diagnosis; Thrombotic microangiopathy
• ISSN: 1473-0502; 1878-1683
• DOI: 10.1016/j.transci.2013.04.014

Abstract 58-year old Caucasian woman was diagnosed with sarcoidosis. Low immunoglobulin levels were found and common variable immunodeficiency (CVID) was diagnosed 1 year later. Laboratory tests and clinical course at this time revealed thrombotic microangiopathy (TMA). Therapeutic plasma exchange was started and her clinical status and laboratory parameters improved. According to CVID she received human immunoglobulin intravenously. Four months later we noticed swelling of the parotid glands and generalized lymphadenopathy. Histology of cervical lymph node confirmed large B-cell non-Hodgkin lymphoma (B-cell NHL). To the best of our knowledge, TMA complicating the course of sarcoidosis, CVID and B-cell NHL has never been reported.