The relationship between severity of the disease and circulating nucleosomes in psoriasis patients

Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α...

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Bibliographic Details
Published in:Archives of Dermatological Research 2013-08, Vol.305 (6), p.483-487
Main Authors: Dilek, Aziz Ramazan, Dilek, Nursel, Saral, Yunus, Yüksel, Derya
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Apoptosis
Biomarkers - blood
Dermatology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Keratinocytes - immunology
Keratinocytes - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Nucleosomes - pathology
Original Paper
Predictive Value of Tests
Prognosis
Psoriasis - blood
Psoriasis - diagnosis
Psoriasis - immunology
Psoriasis - pathology
Severity of Illness Index
Tumor Necrosis Factor-alpha - blood
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Summary:Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an important factor affecting the apoptosis. In the present study, the relationship between TNF-α, nucleosome and the Psoriasis Area and Severity Index (PASI) score was investigated. The patients were divided according to PASI score into three groups (mild, moderately, severe). Serum TNF-α and nucleosome levels were measured using Enzyme-linked immunosorbent assay (ELISA) method. Our findings show a correct relationship between PASI scores and TNF-α and an inverse relationship between nucleosome and PASI score. According to the results obtained from the study, we believe that serum nucleosome levels can be used as a new indicator in follow-up of patients with psoriasis and monitoring of the effectiveness of drugs which used in the treatment of psoriasis.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-013-1347-4